Friday, December 8, 2017

Statins for Control of Cholesterol - Information and Research Review



Statins reduce cholesterol biosyntesis (production of cholesterol), mainly in the liver, due to their  effect of inhibition upon HMG-CoA reductase. The antiatherosclerotic effect comes due to decrease in LDL cholesterol. In addition, they can exert antiatherosclerotic effects independently of their hypolipidemic action. HMG-CoA reductase inhibition (reduction) has beneficial pleiotropic effects and reduce tumor cell growth. Consequently, statins reduced the rate of mortality in coronary patients.
https://www.ncbi.nlm.nih.gov/pubmed/12067471


Lovastatin was the first effective HMGCR inhibitor commercially made available in 1987 by Merck.

https://www.atrainceu.com/course-module/1473411-zzz_76_statins-controlling-cholesterol-module-1


You can think of stopping the medicine or decrease the dose If you reduce risk factors

You have to do it on the advice of the doctor only. It can be thought of only if the level of cholesterol is under control for significant time.

Unless risk factors are significantly modified to reduce weight, increase exercise, control hypertension and diabetes, and stop smoking, cholesterol levels are likely to return to previous values if statin therapy is discontinued.


2017

Statins are safe medicines - They have to be given to people with risk of vascular diseases.
But we are collecting data to investigate the reported problems due to statin use.

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July 2017



2012

Statins Benefit many. A meta-analysis of 27 large statin trials shows that statin treatment is clearly beneficial and has to be given for many with a 10% risk of vascular events in next 10 years (Lancet, 2012b). Then we may avoid 10,000 events, including 2,000 deaths every year.

 The meta-analysis, published in 2012 in the Lancet, was conducted by the Cholesterol Treatment Trialists’ (CTT) Collaborators. They analyzed data from 175,000 individuals by grouping them  into five categories based on high to low  cardiovascular risk.  Results of the based on 27 research studies,  showed that statins reduced the risk of serious vascular events by around 21% for each 1-mmol/L reduction in LDL cholesterol in all groups, including  the lowest risk group.

According to  Colin Baigent (Clinical Trial Service Unit, Oxford, UK), the relative reduction in risk of cardiovascular events with a statin is good even in the lowest-risk group and the benefits greatly exceeded the harms due to the drug.

Half of cardiac deaths happen in people the first time an adverse cardiac event occurs, so there is a limit to what can be achieved secondary prevention (which is treatment after the event and knowledge of the disease). Primary prevention, which is giving drugs to prevent the disease is  needed and therefore a threshold is to be set.

At the moment, the public and many doctors think that statins are necessary only if a patient has high cholesterol. The thinking has to be changed and new view that statin is needed if you are at any increased risk of heart disease has to be accepted and promoted.

Press release on research
https://www.ndm.ox.ac.uk/_asset/file/wider-statin-use-saves-lives-web.pdf

https://www.atrainceu.com/course-module/1552780-zzz_76_statins-controlling-cholesterol-module-5


NHS 'should consider giving statins to healthy people'
By James Gallagher, Health and science reporter, BBC News, 17 May 2012
http://www.bbc.com/news/health-18091708


Colin Baigent - Wider Stating use saves life
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2013 OxfordNDM

Tuesday, November 28, 2017

Whey Protein - Benefits





Advertisement for Whey Protein
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Avvatar India

10 Evidence-Based Health Benefits of Whey Protein

Written by Atli Arnarson, PhD on June 12, 2017

https://www.healthline.com/nutrition/10-health-benefits-of-whey-protein

Monday, November 27, 2017

Daily Rounds - Academic Network of Doctors




https://www.dailyrounds.org/



August 2017

Indian Council of Medical Research- India Diabetes(ICMR-INDIAB) Report 2017
The prevalence of diabetes in the 15 states was 7.3%.
For pre-diabetes, the overall prevalence was 10.3%

https://www.dailyrounds.org/blog/curious-economic-reason-why-doctors-see-ever-more-diabetic-patients-today/


Lancet Diabetes Endocrinol. 2017 Aug;5(8):585-596. doi: 10.1016/S2213-8587(17)30174-2. Epub 2017 Jun 7.
Prevalence of diabetes and prediabetes in 15 states of India: results from the ICMR-INDIAB population-based cross-sectional study.
https://www.ncbi.nlm.nih.gov/pubmed/28601585

Friday, November 24, 2017

Hair Dyes and Cancer Link - Ongoing Research - Findings, Conclusions and Controversies





2017

http://www.news.com.au/lifestyle/beauty/face-body/dark-hair-dye-and-chemical-straighteners-have-been-linked-to-breast-cancer/news-story/2e6b470b92791426e92a3e680fd0b3c8

Hair Dyes Tied to Higher Breast Cancer Risk
Study findings differ by race, but one expert says they're inconclusive
study lead author Adana Llanos.
an assistant professor of epidemiology with the Rutgers School of Public Health and Rutgers Cancer Institute of New Jersey.
https://www.webmd.com/breast-cancer/news/20170620/could-certain-hair-dyes-relaxers-raise-breast-cancer-risk#1

Research suggests link between hair dye and breast cancer
Oct 16, 2017
Professor Kefah Mokbel, surgeon, from London's Princess Grace Hospital,
https://www.9news.com.au/health/2017/10/16/10/21/research-suggests-link-between-hair-dye-and-cancer


Research Papers


Does hair dye use really increase the risk of prostate cancer?

Bang-Ping Jiann
Jiann BMC Cancer (2017) 17:724
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678775/pdf/12885_2017_Article_3656.pdf

Personal use of hair dyes and risk of leukemia: a systematic
literature review and meta-analysis
Kevin M. Towle , Matthew E. Grespin & Andrew D. Monnot
Cancer Medicine 2017; 6(10):2471–2486
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633595/pdf/CAM4-6-2471.pdf

Phd Thesis
Permanent hair dyes. Exposure, diagnostics, and prevention of contact allergy.
Antelmi, Annarita
Published: 2017-01-01
https://lucris.lub.lu.se/ws/files/21393336/2017.02.02_Thesis_AA.pdf





Thursday, November 16, 2017

Health Benefits of Bitter Gourd - Bitter Melon - Karela





Benefits of Bitter Gourd (Karela) Juice
Posted by Srishti Walia | Nov 15, 2017 | Health and Ayurveda
https://www.remedyspot.com/benefits-bitter-gourd-karela-juice/

Control of blood sugar

J Ethnopharmacol. 2011 Mar 24;134(2):422-8. doi: 10.1016/j.jep.2010.12.045. Epub 2011 Jan 4.
Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients.

CONCLUSIONS:
Bitter melon had a modest hypoglycemic effect and significantly reduced fructosamine levels from baseline among patients with type 2 diabetes who received 2,000 mg/day. However, the hypoglycemic effect of bitter melon was less than metformin 1,000 mg/day.

http://food.ndtv.com/food-drinks/7-health-benefits-of-bitter-gourd-karela-juice-1423896



Weight reduction

J Lipids. 2015; 2015: 496169.
Published online 2015 Jan 12. doi:  10.1155/2015/496169
PMCID: PMC4306384
Beneficial Role of Bitter Melon Supplementation in Obesity and Related Complications in Metabolic Syndrome
Md Ashraful Alam, 1 , * Riaz Uddin, 2 Nusrat Subhan, 3 Md Mahbubur Rahman, 1 Preeti Jain, 1 and Hasan Mahmud Reza 1 , *
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306384/

Thursday, November 2, 2017

Ideal Body Composition





Human Body Composition: Approaches and Applications
Josef Brožek
Elsevier, 22-Jan-2016 - Medical - 324 pages


Human Body Composition: Approaches and Applications focuses on approaches to the description of human physique; clarification of the role of factors determining and modifying body composition; and assessment of biological and medical significance of individual differences in body composition.
The selection first discusses advances and developments in the methods for the study of body composition and chemical analysis of the body. Discussions focus on direct and roentgenographic studies of bone mineralization; caliper and roentgenogrammetric values of the thickness of subcutaneous adipose tissue; and soft tissue roentgenography. The text also looks at determination of specific gravity of live sheep and its correlation with fat percentage and interpretation of whole body potassium measurements.
The manuscript evaluates research on body composition and its relevance for human biology, including sex, growth, and aging, physical activity, loss and gain of body weight, and body composition in animals. The book also elaborates on sex difference in body composition, physical activity and body composition, hydrometry of growth and aging, and body composition and appraisal of nutriture.
The selection is a reliable reference for readers interested in the composition of the human body.

See Page 181

https://books.google.co.in/books?id=ikHgBAAAQBAJ


http://homepages.wmich.edu/~ccheatha/hphe4450/files/handouts/Section06-Body%20Composition-Handouts.pdf



International Journal of Obesity
July 2002, Volume 26, Number 7, Pages 953-960

Paper
"Fat-free mass index and fat mass index percentiles in Caucasians aged 18-98 y"

Y Schutz, U U G Kyle and C Pichard


https://www.nature.com/ijo/journal/v26/n7/full/0802037a.html

Sunday, October 29, 2017

About Dementia


Alzheimers

Vascular

Lewy bodies

Majority of cases are Alzheimers

Vascular 10%


Use left hand to write

Dance

Do knitting - use both hands simultaneously.

Friday, October 27, 2017

Weight Reduction - Mantena - అధిక బరువు తగ్గాలంటే - డాక్టర్ మంతెన సత్యనారాయణ రాజు



అధిక బరువు తగ్గాలంటే - డాక్టర్ మంతెన సత్యనారాయణ రాజు

తిన తగినవి -  కూరలు, పళ్ళు, మొలకలు
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అధిక బరువు తగ్గాలంటే - మానవలసినవి

పంచదార, దుంప కూరలు, కొన్ని పళ్ళు - అరటి, మామిడి, ఖర్జూరం, సపోటా
తగ్గించండి - అన్నం

శక్తిని ఇచ్చే పదార్ధములను తగ్గించండి. మాంస కృత్తులు, విటమిన్లు, లోహాలు, ఎంజయ్ములు ఇచ్చే పదార్ధములను తగ్గించకండి. రోజుకు 60 నుండి 70 గ్రాముల మాంస కృత్తులు కావాలి. కాబట్టి మొలకలు ప్రత్యేకించి తినండి.

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మగవారు బరువు స్థిరముగా ఉండాలంటే తిన తగిన ఆహారం
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                            గ్రాములు

caloriesproteins
Rice2254900715.5
pulses                    10044002020
vegetables2501001.53.75
Fruits    200100
milk50030016
fats309270
protinex25908


216063.25





బరువు తగ్గడం కోసం బియ్యం 25 గ్రాముల, పప్పు 25గ్రాములు, నూనె 10 గ్రాములు తగ్గించండి. 290 కెలోరీలు తగ్గుతాయి. అంటే 1870 కెలోరీలు వస్తాయి. ఒక గంట సేపు నడవండి.  బరువు తగ్గు ముఖం పడుతుంది.  ఇంకో 25 గ్రాములు బియ్యం తగ్గించండి. ఇంకొంచెం సేపు ఏమైనా పని ఎక్కువ చెయ్యండి. రోజు బజారుకు నడిచి వెళ్లి సరుకులు కూరలు తేవడము వంటి పనులు ఎక్కువ చేయండి.   బరువు తగ్గించే ప్రయత్నమూ రోజులలో పంచదార, బెల్లం పూర్తిగా మానివేయ్యేది. కాఫీ, టీ  పంచదార లేకుండా త్రాగండి.
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Wednesday, October 25, 2017

Aamir Khan's 25 - 28 Kg Weight Loss Story - 5 Five Month Effort



Aamir Khan gained weight first for his role of an overweight old wrestler (Film Dangal) and lost the extra weight subsequently in 5 months. He had lost weight in the old fashioned way only. Losing one kg per week which requires a deficit of 1100 calories for a day. For that he has taken 1500 calories per day. He consumed 2600 calories per day. But initially, he went to a ranch in Arizona and was active for 8 hours a day to lose 2 kgs per week for 3 weeks. This only gave him a leg up on his weight reduction project and probably gave him the confidence and strong motivation to complete weight reduction in a planned time to be ready for shooting for the same film.


Aamir Khan Reveals his Weight Loss Secret in Dangal Movie

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Upendra Ahire - Upload




Articles on Aamir Khan's Weight Loss of 25 to 28 Kg


http://indianexpress.com/article/lifestyle/fitness/aamir-khans-strict-diet-and-workout-plan-for-his-fat-to-fit-for-dangal-video-4401261/

http://indianexpress.com/article/lifestyle/fitness/aamir-khan-weight-loss-story-secret-for-dangal-2857618/

http://www.hindustantimes.com/bollywood/aamir-khan-s-road-to-weight-loss-in-distant-arizona/story-JxZyU5HowOSSttHQlXsRAI.html

http://www.firstpost.com/entertainment/aamir-khan-fat-to-fit-video-highlights-dramatic-weight-loss-for-dangal-watch-it-here-3129726.html

http://www.theman.in/wellness/the-dangal-diet.html


Amir Khan's Dangal Diet Plan


https://www.tatacliq.com/que/aamirkhan-nutritionist-dangal-diet/


https://dhurandhar.com/category/weight-management-tips/

INTERVIEW
Year : 2014  |  Volume : 1  |  Issue : 1  |  Page : 58-61
A thought that turned into reality -an interview with Dr. Vinod Dhurandhar, founder president AIAARO (All India Association for Advancing Research in Obesity)
http://www.jomrjournal.org/article.asp?issn=WKMP-0058;year=2014;volume=1;issue=1;spage=58;epage=61;aulast=Patankar

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Tuesday, October 24, 2017

Planking - Exercise



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https://fitness.mercola.com/sites/fitness/archive/2014/12/05/5-plank-benefits.aspx


https://www.indiatimes.com/health/healthyliving/7-surprising-benefits-of-doing-the-plank-exercise-everyday-324035.html


The American Council on Exercise
https://www.acefitness.org/education-and-resources/lifestyle/exercise-library/32/front-plank

https://www.acefitness.org/education-and-resources/professional/prosource/february-2014/3680/reality-check-are-planks-really-the-best-core-exercise


http://www.oprah.com/health/plank-variations-for-a-strong-core



There is standing plank also


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https://www.uwhealth.org/uw-carbone-cancer-center/core-strengthening-plank-position/13967






http://www.guinnessworldrecords.com/world-records/longest-time-in-an-abdominal-plank-position

Testosterone - Problem and Treatment

Control Waist to Height Ratio - Prevent High BP, Diabetes and Cholesterol Problems - W/Ht < 0.5



Waist has to be less than half of your height


You waist in inches (cm) has to be less than half of your height in inches (cm).

For example if your are 5 feet 6 inches (66 inches), your waist has to be less than 33 inches.

The risk of developing high blood pressure (blood circulation problem), diabetes (excess glucose in blood), high cholestorol (excess fat in blood) increases as the waist measurement goes about half of height.

There are large number of research studies which are confirming this relation.

When you go to a tailor or to a shop to buy a trouser. don't rejoice if your size has gone up. Immediately take action to reduce it. Do some diet control and increase your exercise to bring the size back to healthy limit.


Salman Khan maintains his waist well within the ratio

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Add to 20 Years to Your Expected Life

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Cass Business School


Some research papers are shown in this video
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Research Studies

2017

https://www.sciencedaily.com/releases/2017/06/170606090942.htm

https://www.health-calc.com/body-composition/waist-to-height-ratio

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463347/

http://journals.lww.com/md-journal/Abstract/2017/09290/Waist_to_height_ratio_is_better_than_body_mass.73.aspx

2013
http://www.onlinejacc.org/content/62/8/742

2011
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549404/


2006
http://care.diabetesjournals.org/content/29/12/2760.1

2003
http://www.nature.com/ijo/journal/v27/n5/full/0802259a.html



Popular Articles

Wikipedia
https://en.wikipedia.org/wiki/Waist-to-height_ratio


How can you reduce waist.

1. Reduce weight.

2. To reduce weight, find out your calories requirement and eat 500 calorie less.

3. Do exercise as you specified in your calorie requirement.

4. Try to walk and do movements for one hour.

5. Do planking exercise.


Indian films starts are maintaining the recommended ratio

Figures collected from various websites in 2017

Akshay kumar

Height 180 cm  5' 11” (71")
Weight 80 kg, 176 lbs
Body Measurements - Chest: 42 Inches - Waist: 34 Inches - Biceps: 16 Inches

Ranbir Kapoor
Height 183 cm,  6' 0”
Weight  78 kg, 172 lbs
Body Measurements - Chest: 42 Inches - Waist: 32 Inches - Biceps: 15 Inches

Varun Dhawan

Height 175 cm, 5' 9”
Weight 78 kg,  172 lbs
Body Measurements - Chest: 40 Inches - Waist: 32 Inches - Biceps: 15 Inches

Sonakshi Sinha

Height 169 cm, 5' 6½”
Weight 70 kg, 154 lbs
Waist 27 inches


More actors' information to be added

Thursday, September 28, 2017

Benefits Standing for some time over Sitting for Prolonged Periods of Time




http://www.livestrong.com/article/73916-calories-burned-standing-vs.-sitting/


http://www.bbc.com/news/magazine-24532996

https://www.btod.com/blog/2017/03/04/how-many-calories-will-i-burn-standing-vs-sitting/

http://www.startstanding.org/calculate-calories-burned-sitting-vs-standing/


Standing versus Sitting: kilocalories expended per minute (1.36 ± 0.20 kcal/min, P ≤ .0001 vs. 1.02 ± 0.22 kcal/min, P ≤ .0001).
https://www.ncbi.nlm.nih.gov/pubmed/22971879


https://medlineplus.gov/ency/patientinstructions/000894.htm


https://well.blogs.nytimes.com/2016/06/22/how-many-calories-we-burn-when-we-sit-stand-or-walk/

Tuesday, September 26, 2017

7-Day GM Diet for Weight Reduction



Many persons are vouchsafing for the GM diet weight loss. Especially, when weight reduction is not taking place in any plan, alternatives are to be looked for. GM diet is one alternative people are recommending. I think GM diet uses Atkins diet philosophy on day 5 and day 6 when protein and fat are the main inputs.


Interesting Web Sites


https://www.icicilombard.com/insurancevideos/gm-diet-food.html  (Simple video included)


http://www.news.com.au/lifestyle/health/diet/the-gm-diet-is-7kg-weight-loss-in-a-week-realistic/news-story/5ce0216c9d362aab501d3239bdd5bf64


http://www.dailymail.co.uk/femail/article-4744798/GM-Diet-sees-lose-SEVEN-kilos-just-one-week.html    (Good simple explanation with pictures)


GM Diet  - Day 1  -  Day 2  -  Day 3 - Day 4 - Day 5 - Day 6 - Day 7


Day 1  - Only fruits - All except banana

Day 2 - Only vegetables - cooked or raw - Only one potato per day.

Day 3 - Fruits and vegetables combination - No potatoes.

Day 4 - 6 to 8 bananas and 3 to 4 glasses of milk.

Day 5 - 400 gms of lean beef, 6 to 8 tomatos. - Use paneer in place of meat.

Day 6 - 400 gms of lean beef and vegetables - Use paneer in place of meat.

Day 7 - Brown rice for Lunch and vegetables



Vegetarians can take Paneer in place of Lean Beef.  Compare the nutrients.

Lean Beef


Lean Beef contains per 100 gms (when it is 5% fat type)

                   100g raw as sold contains
Energy              520kJ (124kcal)
Fat                       4.5g
Saturates               2.0g
Carbohydrate        0g - No carbohydrates
Sugars                0g
Fibre                0g
Protein             20.8g
Salt                        0.3g


Paneer


100 gms of paneer made from cow milk provides

18.3 gms of protein,
20.8 gms of fat,
2.6 gms of minerals,
1.2 gms of carbohydrates, - Very small amount of carbohydrates
265 kcal of energy,
208 mgs of calcium,
138 mg of phosphorous.

In paneer fat is more. In lean meats also there are different types. 20% fat lean meats are there. So one should not worry about. 

Wednesday, September 20, 2017

Nut Consumption - Health Benefits




Health Benefits of Nut Consumption

Emilio Ros
Article published in Nutrients. 2010 Jul; 2(7): 652–682.

Nuts (tree nuts and groundnuts are nutrient dense foods rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds.  Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease and gallstones in both genders and diabetes in women.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257681/

Half a handful of nuts a day 'reduces early death risk'
June 2015
https://www.nhs.uk/news/food-and-diet/half-a-handful-of-nuts-a-day-reduces-early-death-risk/




10 grams of nuts per day is one recommendation

10 grams of peanuts = 12 peanuts
10 grams of almonds = 8–9 almonds
10 grams of cashews = 6 cashews



https://www.prevention.com/health/eat-nuts-prevent-diabetes-and-heart-disease

http://food.ndtv.com/opinions/the-nutty-affair-just-how-much-of-these-nuts-should-you-be-eating-779321

http://www.livestrong.com/article/461516-do-peanuts-cause-weight-gain/


Peatnut nutrition:  http://www.nutrition-and-you.com/peanuts.html

Principle Nutrient Value Percent of RDA
Energy 567 Kcal 29%
Carbohydrates 16.13 g 12%
Protein 25.80 g 46%
Total Fat 49.24 g 165%
Cholesterol 0 mg 0%
Dietary Fiber 8.5 g 22%
Vitamins
Folates 240 µg 60%
Niacin 12.066 mg 75%
Pantothenic acid 1.767 mg 35%
Pyridoxine 0.348 mg 27%
Riboflavin 0.135 mg 10%
Thiamin 0.640 mg 53%
Vitamin A 0 IU 0%

Bioelectric Impedance Analysis - BIA Devices to Measure Body Fat Percentages

Wednesday, July 26, 2017