Statins reduce cholesterol biosyntesis (production of cholesterol), mainly in the liver, due to their effect of inhibition upon HMG-CoA reductase. The antiatherosclerotic effect comes due to decrease in LDL cholesterol. In addition, they can exert antiatherosclerotic effects independently of their hypolipidemic action. HMG-CoA reductase inhibition (reduction) has beneficial pleiotropic effects and reduce tumor cell growth. Consequently, statins reduced the rate of mortality in coronary patients. https://www.ncbi.nlm.nih.gov/pubmed/12067471
Lovastatin was the first effective HMGCR inhibitor commercially made available in 1987 by Merck.
You can think of stopping the medicine or decrease the dose If you reduce risk factors
You have to do it on the advice of the doctor only. It can be thought of only if the level of cholesterol is under control for significant time.
Unless risk factors are significantly modified to reduce weight, increase exercise, control hypertension and diabetes, and stop smoking, cholesterol levels are likely to return to previous values if statin therapy is discontinued.
Statins are safe medicines - They have to be given to people with risk of vascular diseases.
But we are collecting data to investigate the reported problems due to statin use.
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July 2017
2012
Statins Benefit many. A meta-analysis of 27 large statin trials shows that statin treatment is clearly beneficial and has to be given for many with a 10% risk of vascular events in next 10 years (Lancet, 2012b). Then we may avoid 10,000 events, including 2,000 deaths every year.
The meta-analysis, published in 2012 in the Lancet, was conducted by the Cholesterol Treatment Trialists’ (CTT) Collaborators. They analyzed data from 175,000 individuals by grouping them into five categories based on high to low cardiovascular risk. Results of the based on 27 research studies, showed that statins reduced the risk of serious vascular events by around 21% for each 1-mmol/L reduction in LDL cholesterol in all groups, including the lowest risk group.
According to Colin Baigent (Clinical Trial Service Unit, Oxford, UK), the relative reduction in risk of cardiovascular events with a statin is good even in the lowest-risk group and the benefits greatly exceeded the harms due to the drug.
Half of cardiac deaths happen in people the first time an adverse cardiac event occurs, so there is a limit to what can be achieved secondary prevention (which is treatment after the event and knowledge of the disease). Primary prevention, which is giving drugs to prevent the disease is needed and therefore a threshold is to be set.
At the moment, the public and many doctors think that statins are necessary only if a patient has high cholesterol. The thinking has to be changed and new view that statin is needed if you are at any increased risk of heart disease has to be accepted and promoted.
NHS 'should consider giving statins to healthy people'
By James Gallagher, Health and science reporter, BBC News, 17 May 2012 http://www.bbc.com/news/health-18091708
Colin Baigent - Wider Stating use saves life
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Indian Council of Medical Research- India Diabetes(ICMR-INDIAB) Report 2017
The prevalence of diabetes in the 15 states was 7.3%.
For pre-diabetes, the overall prevalence was 10.3%
Lancet Diabetes Endocrinol. 2017 Aug;5(8):585-596. doi: 10.1016/S2213-8587(17)30174-2. Epub 2017 Jun 7.
Prevalence of diabetes and prediabetes in 15 states of India: results from the ICMR-INDIAB population-based cross-sectional study. https://www.ncbi.nlm.nih.gov/pubmed/28601585
J Ethnopharmacol. 2011 Mar 24;134(2):422-8. doi: 10.1016/j.jep.2010.12.045. Epub 2011 Jan 4.
Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients.
CONCLUSIONS:
Bitter melon had a modest hypoglycemic effect and significantly reduced fructosamine levels from baseline among patients with type 2 diabetes who received 2,000 mg/day. However, the hypoglycemic effect of bitter melon was less than metformin 1,000 mg/day.
J Lipids. 2015; 2015: 496169.
Published online 2015 Jan 12. doi: 10.1155/2015/496169
PMCID: PMC4306384
Beneficial Role of Bitter Melon Supplementation in Obesity and Related Complications in Metabolic Syndrome
Md Ashraful Alam, 1 , * Riaz Uddin, 2 Nusrat Subhan, 3 Md Mahbubur Rahman, 1 Preeti Jain, 1 and Hasan Mahmud Reza 1 , * https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306384/
Human Body Composition: Approaches and Applications
Josef Brožek
Elsevier, 22-Jan-2016 - Medical - 324 pages
Human Body Composition: Approaches and Applications focuses on approaches to the description of human physique; clarification of the role of factors determining and modifying body composition; and assessment of biological and medical significance of individual differences in body composition.
The selection first discusses advances and developments in the methods for the study of body composition and chemical analysis of the body. Discussions focus on direct and roentgenographic studies of bone mineralization; caliper and roentgenogrammetric values of the thickness of subcutaneous adipose tissue; and soft tissue roentgenography. The text also looks at determination of specific gravity of live sheep and its correlation with fat percentage and interpretation of whole body potassium measurements.
The manuscript evaluates research on body composition and its relevance for human biology, including sex, growth, and aging, physical activity, loss and gain of body weight, and body composition in animals. The book also elaborates on sex difference in body composition, physical activity and body composition, hydrometry of growth and aging, and body composition and appraisal of nutriture.
The selection is a reliable reference for readers interested in the composition of the human body.
శక్తిని ఇచ్చే పదార్ధములను తగ్గించండి. మాంస కృత్తులు, విటమిన్లు, లోహాలు, ఎంజయ్ములు ఇచ్చే పదార్ధములను తగ్గించకండి. రోజుకు 60 నుండి 70 గ్రాముల మాంస కృత్తులు కావాలి. కాబట్టి మొలకలు ప్రత్యేకించి తినండి.
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మగవారు బరువు స్థిరముగా ఉండాలంటే తిన తగిన ఆహారం
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గ్రాములు
calories
proteins
Rice
225
4
900
7
15.5
pulses
100
4
400
20
20
vegetables
250
100
1.5
3.75
Fruits
200
100
milk
500
300
16
fats
30
9
270
protinex
25
90
8
2160
63.25
బరువు తగ్గడం కోసం బియ్యం 25 గ్రాముల, పప్పు 25గ్రాములు, నూనె 10 గ్రాములు తగ్గించండి. 290 కెలోరీలు తగ్గుతాయి. అంటే 1870 కెలోరీలు వస్తాయి. ఒక గంట సేపు నడవండి. బరువు తగ్గు ముఖం పడుతుంది. ఇంకో 25 గ్రాములు బియ్యం తగ్గించండి. ఇంకొంచెం సేపు ఏమైనా పని ఎక్కువ చెయ్యండి. రోజు బజారుకు నడిచి వెళ్లి సరుకులు కూరలు తేవడము వంటి పనులు ఎక్కువ చేయండి. బరువు తగ్గించే ప్రయత్నమూ రోజులలో పంచదార, బెల్లం పూర్తిగా మానివేయ్యేది. కాఫీ, టీ పంచదార లేకుండా త్రాగండి.
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Aamir Khan gained weight first for his role of an overweight old wrestler (Film Dangal) and lost the extra weight subsequently in 5 months. He had lost weight in the old fashioned way only. Losing one kg per week which requires a deficit of 1100 calories for a day. For that he has taken 1500 calories per day. He consumed 2600 calories per day. But initially, he went to a ranch in Arizona and was active for 8 hours a day to lose 2 kgs per week for 3 weeks. This only gave him a leg up on his weight reduction project and probably gave him the confidence and strong motivation to complete weight reduction in a planned time to be ready for shooting for the same film.
Aamir Khan Reveals his Weight Loss Secret in Dangal Movie
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Upendra Ahire - Upload
Articles on Aamir Khan's Weight Loss of 25 to 28 Kg
You waist in inches (cm) has to be less than half of your height in inches (cm).
For example if your are 5 feet 6 inches (66 inches), your waist has to be less than 33 inches.
The risk of developing high blood pressure (blood circulation problem), diabetes (excess glucose in blood), high cholestorol (excess fat in blood) increases as the waist measurement goes about half of height.
There are large number of research studies which are confirming this relation.
When you go to a tailor or to a shop to buy a trouser. don't rejoice if your size has gone up. Immediately take action to reduce it. Do some diet control and increase your exercise to bring the size back to healthy limit.
Salman Khan maintains his waist well within the ratio
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Add to 20 Years to Your Expected Life
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Cass Business School
Some research papers are shown in this video
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Standing versus Sitting: kilocalories expended per minute (1.36 ± 0.20 kcal/min, P ≤ .0001 vs. 1.02 ± 0.22 kcal/min, P ≤ .0001).
https://www.ncbi.nlm.nih.gov/pubmed/22971879
Many persons are vouchsafing for the GM diet weight loss. Especially, when weight reduction is not taking place in any plan, alternatives are to be looked for. GM diet is one alternative people are recommending. I think GM diet uses Atkins diet philosophy on day 5 and day 6 when protein and fat are the main inputs.
Day 2 - Only vegetables - cooked or raw - Only one potato per day.
Day 3 - Fruits and vegetables combination - No potatoes.
Day 4 - 6 to 8 bananas and 3 to 4 glasses of milk.
Day 5 - 400 gms of lean beef, 6 to 8 tomatos. - Use paneer in place of meat.
Day 6 - 400 gms of lean beef and vegetables - Use paneer in place of meat.
Day 7 - Brown rice for Lunch and vegetables
Vegetarians can take Paneer in place of Lean Beef. Compare the nutrients.
Lean Beef
Lean Beef contains per 100 gms (when it is 5% fat type)
100g raw as sold contains
Energy 520kJ (124kcal)
Fat 4.5g
Saturates 2.0g
Carbohydrate 0g - No carbohydrates
Sugars 0g
Fibre 0g
Protein 20.8g
Salt 0.3g
Paneer
100 gms of paneer made from cow milk provides
18.3 gms of protein,
20.8 gms of fat,
2.6 gms of minerals,
1.2 gms of carbohydrates, - Very small amount of carbohydrates
265 kcal of energy,
208 mgs of calcium,
138 mg of phosphorous.
In paneer fat is more. In lean meats also there are different types. 20% fat lean meats are there. So one should not worry about.
Emilio Ros
Article published in Nutrients. 2010 Jul; 2(7): 652–682.
Nuts (tree nuts and groundnuts are nutrient dense foods rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds. Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease and gallstones in both genders and diabetes in women. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257681/