Excess Salt May Make Arteries Stiff and Cause Vascular Problems

Data from both animal and human studies provide evidence that salt impairs endothelial function and increases arterial stiffness independent of blood pressure.
Vascular Effects of Dietary Salt
David G. Edwards and William B. Farquhar
Curr Opin Nephrol Hypertens. Author manuscript; available in PMC 2017 May 15.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431073/

Heart failure and salt: The great debate

December 18, 2018

https://www.health.harvard.edu/blog/heart-failure-and-salt-the-great-debate-2018121815563

Vascular Stiffness in Aging and Disease

REVIEW article

Front. Physiol., 07 December 2021

Sec. Vascular Physiology

https://doi.org/10.3389/fphys.2021.762437

This article is part of the Research Topic

Cardiovascular Remodeling in Aging and Disease

https://www.frontiersin.org/articles/10.3389/fphys.2021.762437/full

Effects of Sodium Intake on Health and Performance in Endurance and Ultra-Endurance Sports

by Eleftherios Veniamakis 1,Georgios Kaplanis 1,Panagiotis Voulgaris 1 andPantelis T. Nikolaidis 2,*ORCID

1

Department of Nutrition and Dietetics, Hellenic Mediterranean University, 72300 Sitia, Greece

2

School of Health and Caring Sciences, University of West Attica, 12243 Athens, Greece

*

Author to whom correspondence should be addressed.

Academic Editor: Alberto Pérez-López

Int. J. Environ. Res. Public Health 2022, 19(6), 3651; https://doi.org/10.3390/ijerph19063651

Received: 26 January 2022 / Revised: 3 March 2022 / Accepted: 8 March 2022 / Published: 19 March 2022

https://www.mdpi.com/1660-4601/19/6/3651/htm

Dietary Sodium Restriction Reverses Vascular Endothelial Dysfunction in Middle-Aged/Older Adults With Moderately Elevated Systolic Blood Pressure

FREE ACCESS

Hypertension

Kristen L. Jablonski, Matthew L. Racine, Candace J. Geolfos, Phillip E. Gates, Michel Chonchol, Matthew B. McQueen, and Douglas R. Seals

J Am Coll Cardiol. 2013 Jan, 61 (3) 335–343

Clinical significance

The concept that high sodium intake has adverse CV effects independent of BP has been advanced previously (9,12). High dietary sodium impairs EDD even in rodents that are salt-resistant and, thus, do not exhibit increases in BP in response to a high-salt diet (13,18,20). Acute impairment of EDD in normotensive adults after sodium loading also is BP independent (11), and adults with elevated SBP who report lower sodium intake have enhanced EDD independent of BP (16). The present results extend these findings to sodium restriction and lend support to the overall hypothesis that sodium intake not only elevates BP but also exerts other adverse influences (12). The effects of sodium restriction on endothelial function reported here also complement previous findings that reducing sodium intake can rapidly de-stiffen large elastic arteries (21), another independent vascular risk factor for CVD (40). The improvements in these 2 common forms of arterial dysfunction, both predictors of CV events (3,4,40), suggest that DSR has strong potential for reducing CVD risk via broad vasculoprotective effects.

https://www.jacc.org/doi/10.1016/j.jacc.2012.09.010

ud. 12.6.2024,   24.9.2022, 17.9.2022

pub. 25.9.2019