Cobalamin is the only water-soluble vitamin stored in the body. About 3 mg of cobalamin are stored, of which 1 mg is stored in the liver. Hence, it takes 3-5 years to develop a vitamin B12 deficiency after a total gastrectomy. In contrast, significant amounts of folate are not stored. Clinical evidence of folate deficiency can occur within a month after folate intake is stopped.
https://www.medscape.com/answers/204066-119195/what-is-the-role-of-cobalamin-and-folate-storage-in-the-pathogenesis-of-megaloblastic-anemia
https://www.b12-vitamin.com/body-store/
However, this impression is put into perspective if you consider the actual intake: from the 1000 µg, only a maximum of 12 µg is actually absorbed by the body with a single oral dose; only 480% of the daily requirement (2).
https://www.b12-vitamin.com/high-dose/
One review recommended that those with vitamin B12 deficiency take 1 mg of vitamin B12 daily for a month, followed by a maintenance dose of 125–250 mcg per day (18Trusted Source).
https://www.healthline.com/nutrition/vitamin-b12-dosage#suggested-dosages
Typically, about 56 percent of a 1-microgram dose of B-12 is absorbed, and that rate of absorption decreases drastically if you take more than 2 micrograms at a time, the Office of Dietary Supplements explains. For example, if you take a 500-microgram pill, your body absorbs only about 10 micrograms.
But a normal level of vitamin B12 in your bloodstream is generally between 190 and 950 picograms per milliliter (pg/mL). Between 200 to 300 pg/mL is considered borderline and your doctor may do more testing. Below 200 pg/mL is low and more testing is needed.
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