Weight Loss and Weight Gain - Science - Research Papers

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Research Papers

2022

Rethinking healthy eating in light of the gut microbiome

Anissa M. Armet, Edward C. Deehan, Aidan F. O’Sullivan, Carla M. Prado, Alice J. Lucey, Jens Walter

Open ArchiveDOI:https://doi.org/10.1016/j.chom.2022.04.016

REVIEW| VOLUME 30, ISSUE 6, P764-785, JUNE 08, 2022Download Full Issue

PDF [3 MB]

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00222-0

Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care

Nicolas J. Pillon

Ruth J.F. Loos

Sally M. Marshall

Juleen R. Zierath

Open AccessPublished:March 05, 2021DOI:https://doi.org/10.1016/j.cell.2021.02.012

REVIEW| VOLUME 184, ISSUE 6, P1530-1544, MARCH 18, 2021

https://www.cell.com/cell/fulltext/S0092-8674(21)00162-8

2017

Our Gut Microbiome: The Evolving Inner Self

Parag Kundu 5

Eran Blacher 5

Eran Elinav

Sven Pettersson 6

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Open ArchiveDOI:

https://doi.org/10.1016/j.cell.2017.11.024

REVIEW| VOLUME 171, ISSUE 7, P1481-1493, DECEMBER 14, 2017Download Full Issue

PDF [2 MB]

Are Gut Microbes Responsible for Post-dieting Weight Rebound?

Julien Chilloux

Marc-Emmanuel Dumas

Obesity has reached pandemic proportions, affecting one-third of humanity, causing greater than 3.4 million deaths, and incurring a loss of quality of life and life expectancy (Ng et al., 2014), as it is a major risk factor for developing type 2 diabetes and cardiovascular disease. The onset of obesity is complex, resulting from the interaction between genetic and environmental factors. Much of the clinical effort to treat obesity targets weight loss, which is a direct and measureable outcome. It turns out this is often the easy part of the job—difficulties arise when trying to maintain weight (Hill, 2004). Dieting is a means to an end for people who want to lose weight, yet when they stop dieting, they put more weight on.

With about 10 million genes (Li et al., 2014), the gut microbiome dwarfs the human genome and is now thought to be a major factor contributing to obesity (Ridaura et al., 2013) as it is significantly altered by Western-style high-fat diets (HFDs) (David et al., 2014). However, due to the complex interaction of the diet, the microbiome, and energy expenditure, the identification of causal mediators of weight rebound remains a major unaddressed challenge. In a recent article, Thaiss et al., 2016 demonstrate how the gut microbiome is involved in post-dieting weight rebound through energy expenditure and how supplementing mice with flavonoids overrides this phenomenon, eventually resetting the rebound clock.

Open ArchiveDOI:https://doi.org/10.1016/j.cmet.2016.12.016

PREVIEW| VOLUME 25, ISSUE 1, P6-7, JANUARY 10, 2017Download Full Issue

PDF [421 KB]

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30649-0

2013

The Origins and Drivers of Insulin Resistance

Andrew M.F. Johnson

Jerrold M. Olefsky

Open ArchiveDOI:   

https://doi.org/10.1016/j.cell.2013.01.041

PERSPECTIVE| VOLUME 152, ISSUE 4, P673-684, FEBRUARY 14, 2013Download Full Issue

PDF [696 KB]