It is not be neglected. It can be the early symptom of cardiovascular problems. There is need to consult doctor and do the treatment as prescribed.
Experts now believe that erectile dysfunction preceding heart problems is more often due to the dysfunction of the inner lining of the blood vessels (endothelium) and smooth muscle. Endothelial dysfunction causes inadequate and impaired blood flow to the penis leading to ED. It also results in inadequate blood supply to the heart and it aids in the development of atherosclerosis, which is buildup of plaque.
Free Access
Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease
Trinity J. Bivalacqua, Mustafa F. Usta, Hunter C. Champion, Philip J. Kadowitz, Wayne J. G. Hellstrom
First published: 02 January 2013 https://doi.org/10.1002/j.1939-4640.2003.tb02743.x
https://onlinelibrary.wiley.com/doi/10.1002/j.1939-4640.2003.tb02743.x
The corpus cavernosum of the penis is composed of a meshwork of interconnected smooth muscle cells lined by vascular endothelium. Of note, endothelial cells and underlying smooth muscle also line the small resistance helicine arteries that supply blood to the corpus cavernosum during penile tumescence. Pathological alteration in the anatomy of the penile vasculature or impairment of any combination of neurovascular processes can result in ED.
https://my.clevelandclinic.org/health/body/23471-endothelium
Blood Vessels and Endothelial Cells
https://www.ncbi.nlm.nih.gov/books/NBK26848/
Tadalafil in the treatment of erectile dysfunction
PDE5 Inhibitors
Armaan Dhaliwal; Mohit Gupta.
Last Update: April 10, 2023.
https://www.ncbi.nlm.nih.gov/books/NBK549843/
Tadalafil in the treatment of erectile dysfunction
Robert M Coward and Culley C Carson
Ther Clin Risk Manag. 2008 Dec; 4(6): 1315–1330.
Published online 2008 Dec. doi: 10.2147/tcrm.s3336
PMCID: PMC2643112
PMID: 19337438
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643112/
Originally Published 28 August 2006
Free Access
Effect of Regular Phosphodiesterase Type 5 Inhibition in Hypertension
James J. Oliver, Vanessa P. Melville, and David J. Webb
https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000239816.13007.c9
Adverse Effects
25 persons were in the study
Two subjects were withdrawn while taking sildenafil, 1 because of severe headache (after 3 days) and the other because of back pain and feeling generally unwell (after 6 days), and 1 subject was withdrawn while taking placebo, because of joint pains, nausea, and headache (after 11 days). For a full summary of the symptoms experienced see the online supplement. Dyspepsia occurred in 10 subjects with sildenafil and lasted ≤5 days. Headaches occurred in 8 subjects and were generally mild and transient. Low back/buttock/leg muscle ache occurred in 7 subjects, was usually responsive to simple analgesia, and tended to settle within a few days. Plasma creatine kinase concentrations were measured in 4 of the subjects who experienced these symptoms, and all were within the normal laboratory reference range. Six of the 18 men in the study reported increased penile erection, which occurred only with sildenafil.
Ud. 12.6.2024
Pub. 30.4.2023
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