Reduction of LDL Cholesterol

 Studies have found that if the LDL cholesterol is reduced to less than 70 mg/dL and preferably less than 55 mg/dL, the size of the plaques can get smaller.19-Jul-2021

https://www.uptodate.com/contents/high-cholesterol-and-lipid-treatment-options-beyond-the-basics

Safety and Efficacy of Extremely Low LDL-Cholesterol Levels and Its Prospects in Hyperlipidemia Management

Dhrubajyoti Bandyopadhyay,corresponding author 1 Arshna Qureshi, 2 Sudeshna Ghosh, 3 Kumar Ashish, 4 Lyndsey R. Heise, 5 Adrija Hajra, 6 and Raktim K. Ghosh 7

J Lipids. 2018; 2018: 8598054. Published online 2018 Apr 23. doi: 10.1155/2018/8598054

PMCID: PMC5937425PMID: 29850255

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937425/

PCSK9 Therapies

Inclisiran from Novartis

Inclisiran - It Was To Be The Cholesterol Drug For The Masses. Novartis Changed That.

John LaMattinaContributor

I cover news on drugs and R&D in the pharma industry

Jan 3, 2022,

https://www.forbes.com/sites/johnlamattina/2022/01/03/it-was-to-be-the-cholesterol-drug-for-the-masses-novartis-changed-that/ 

Two PCSK9 antibodies were approved by the FDA in 2015: Praluent (Sanofi/Regeneron) and Repatha (Amgen). Unfortunately, the list prices of these much anticipated drugs were initially set at a jaw dropping $14,000/year/patient.

in 2018 first Amgen, then Sanofi/Regeneron lowered the list prices to $5,850, hoping that higher sales would ensue. 

In India, Price on 26.9.2022

Repatha Sure Click Evolocumab 140mg Mg Solution For Injection in Prefilled Syringe

₹ 19,500/ PIECE

Usage/Application: Personal

size: 1 PREFILLED PEN DEVICE(s)

Treatment: Heart disorders

Manufacturer: DR REDDY'S LABORATORIES LTD

Strength: 140mg

Brand: EVOLOCUMAB

(Two injections per month are needed.)