Hypothyroidism and Insulin Resistance

Study of insulin levels in hypothyroidism patients

Guddanti Rajeswari1*, Pasagadugula Satya Gopal1, Pasagadugula Satya Srinivas2, Eadala Suresh3 

1Department of Biochemistry, 3Department of Pharmacology, Rangaraya Medical College, Kakinada, Andhra Pradesh, India

2Department of Surgery, ACSR Government Medical College, Nellore, Andhra Pradesh, India

https://www.msjonline.org/index.php/ijrms/article/view/1645/1565

In hypothyroidism because of altered metabolism of lipid and insulin,  binding of insulin to insulin receptor decreases. Impaired translocation of GLUT-4 glucose transporters on plasma membrane occurs, resulting in decreased glucose uptake in muscles and adipose tissue occurs. 

It was postulated that elevated total cholesterol levels and dyslipidemia may act as one of the main culprit for development of insulin resistance in hypothyroidism. Our study combined with previous studies provides an evidence of presence of insulin resistance in SCH patients.

CONCLUSIONS

Our study confirms that hypercholesterolemia and insulin resistance correlate positively with hypothyroidism status. Hence it will be good practice to screen people for presence of Sub Clinical Hypothyroidism and insulin resistance, so that early detection and prompt intervention can prevent or prolong the appearance of various fatal complications associated with insulin resistance in hypothyroidism.

More articles

https://medcraveonline.com/EMIJ/the-role-of-insulin-resistancehyperinsulinism-in-the-evolution-of-thyroid-nodular-disease-in-humans.html

https://clinicaltrials.gov/ct2/show/NCT02467244

Endocrine . 2011 Aug;40(1):95-101. doi: 10.1007/s12020-011-9446-5. Epub 2011 Mar 18.

Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy

https://pubmed.ncbi.nlm.nih.gov/21424182/

https://www.researchgate.net/publication/260253271_Insulin_resistance_and_thyroid_disorders/link/569c10a108ae6169e562793d/download

Association between altered thyroid state and insulin resistance

Kunal B. Kapadia, Parloop A. Bhatt,1 and Jigna S. Shah

J Pharmacol Pharmacother. 2012 Apr-Jun; 3(2): 156–160.

Eight euthyroid (EU), eight hypothyroid (HO), and eight hyperthyroid (HR) patients with no past medical history were studied in this cross-sectional study at the Care Institute of Medical Sciences, Ahmedabad, India,

HOMA values were significantly higher in HR and HO groups as compared to the EU group (P < 0.05). Insulin levels were also found to be significantly increased in HR and HO groups as compared to the EU group (P < 0.05). Cholesterol, triglycerides (TG), and low density lipoprotein (LDL) were significantly raised in HO as compared to EU and HR groups (P < 0.05) whereas high density lipoprotein levels (HDL) were lower. HOMA and insulin were found to be positively correlated with TSH in HO and negatively in HR.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356957/

Why Can Insulin Resistance Be a Natural Consequence of Thyroid Dysfunction?

Volume 2011 |Article ID 152850 | https://doi.org/10.4061/2011/152850

https://www.hindawi.com/journals/jtr/2011/152850/