1957-1958 Pandemic (H2N2 virus) - 1.1 Million Deaths Worldwide

In February 1957, a new influenza A (H2N2) virus emerged in East Asia, triggering a pandemic (“Asian Flu”). This H2N2 virus was comprised of three different genes from an H2N2 virus that originated from an avian influenza A virus, including the H2 hemagglutinin and the N2 neuraminidase genes. It was first reported in Singapore in February 1957, Hong Kong in April 1957, and in coastal cities in the United States in summer 1957.

The estimated number of deaths was 1.1 million worldwide and 116,000 in the United States.

https://www.cdc.gov/flu/pandemic-resources/1957-1958-pandemic.html