Thursday, June 27, 2024

Varicose Veins - Issues

 


Causes

Weak or damaged valves can lead to varicose veins. Arteries carry blood from the heart to the rest of the body. Veins return blood from the rest of the body to the heart. To return blood to the heart, the veins in the legs must work against gravity.


Muscle contractions in the lower legs act as pumps, and elastic vein walls help blood return to the heart. Tiny valves in the veins open as blood flows toward the heart, then close to stop blood from flowing backward. If these valves are weak or damaged, blood can flow backward and pool in the veins, causing the veins to stretch or twist.

https://www.mayoclinic.org/diseases-conditions/varicose-veins/symptoms-causes/syc-20350643


Vain Diseases or Problems

case of iliac vein compression: a mid-40s woman who suffered from leg and buttock heaviness and achiness.

Authors: Back Kim MD &  Tae An Choi, ANP-BC

Heart Vein NYC, New York, New York

https://www.heartveinnyc.com/case-studies/case-of-iliac-vein-compression-a-mid-40s-woman-who-suffered-from-leg-and-buttock-heaviness-and-achiness/


https://www.jvsvenous.org/article/S2213-333X(18)30419-0/fulltext


Diet for Varicose Veins

https://www.blogaberry.com/health-and-fitness/how-a-therapeutic-diet-can-also-heal-painful-varicose-veins/


Exercises for Varicose Veins

https://heritagehospitals.com/blog/10-best-exercises-for-varicose-veins/

https://njvvc.com/how-exercise-promotes-healthy-veins/


ud. 6.2.2024

pub. 14.12.2022










Tuesday, June 25, 2024

Flow-mediated dilation - FMD

 

Flow-mediated dilation (FMD) refers to dilation (widening) of an artery when blood flow increases in that artery. The primary cause of FMD is release of nitric oxide by endothelial cells.


Normotensive overweight/obese patients who were salt restricted for six weeks showed an endothelin 1 (ET-1) decrease of 14% associated with a 45% increase in FMD.


Endothelin-1 (ET-1) is a peptide that plays a crucial role in regulating various physiological processes in the human body. It is primarily produced and secreted by endothelial cells, which are the cells that line the inner walls of blood vessels. ET-1 is a potent vasoconstrictor, meaning it causes blood vessels to constrict or narrow. ET-1 has been shown to be one of the most potent vasoconstrictors.1


https://www.astrazeneca.com/what-science-can-do/topics/disease-understanding/endothelin-1.html







Brachial Artery Flow-Mediated Dilation in Healthy Men, Men with Risk Factors, and Men with Acute Myocardial Infarction. Importance of Occlusion-Cuff Position
https://www.revespcardiol.org/en-brachial-artery-flow-mediated-dilation-in-articulo-13038881



Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Exercise Therapy in the Management of Peripheral Arterial Disease.
 pdf
by AO Hallak · 2023 · flow-mediated dilation, consistent with an improvement in endothelial health


Another study of endothelial function in patients with CAD and post-myocardial infarction revealed improved endothelial function after ET, regardless of the type of training. However, the improvement
noticed disappeared after 1 month of detraining.


February 23, 2024
30-Day Atorvastatin Improved Brachial Artery FMD in Patients With HFpEF, but More Research Is Needed




Long-term Successful Weight Loss Improves Vascular Endothelial Function in Severely Obese Individuals
Sherman J. Bigornia, Melanie M. Mott, Donald T. Hess, Caroline M. Apovian, Marie E. McDonnell, Mai-Ann Duess, Matthew A. Kluge … See all authors 
First published: 06 September 2012 https://doi.org/10.1038/oby.2009.482



Weight Reduction With Very-Low-Caloric Diet and Endothelial Function in Overweight Adults: Role of Plasma Glucose
Maria Raitakari, Thomas Ilvonen, Markku Ahotupa, Terho Lehtimäki, Aimo Harmoinen, Pauli Suominen, Juhani Elo, Jaakko Hartiala, and Olli T. RaitakariAUTHOR INFO & AFFILIATIONS
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume 24, Number 1
https://doi.org/10.1161/01.ATV.0000109749.11042.7

The vascular endothelium plays an important role in the regulation of arterial tone, thrombosis, and inflammation.

 Endothelial dysfunction may predispose arteries to the development of atherosclerotic lesions and is pathophysiologically linked to acute cardiovascular syndromes.1 A common condition that gives rise to  endothelial dysfunction is obesity. Endothelial-dependent vascular responses to both agonist-stimulated2,3 and flow-mediated vasodilation4 have been shown to be blunted in obese individuals.


Atherosclerotic lesions

Atherosclerosis
Aldons J. Lusis

The early lesions of atherosclerosis consist of subendothelial accumulations of cholesterol-engorged macrophages, called ‘foam cells’. In humans, such ‘fatty streak’ lesions can usually be found in the aorta in the first decade of life, the coronary arteries in the second decade, and the cerebral arteries in the third or fourth decades. 

Fatty streaks are not clinically significant, but they are the precursors of more advanced lesions characterized by the accumulation of lipid-rich necrotic debris and smooth muscle cells (SMCs). Such ‘fibrous lesions’ typically have a ‘fibrous cap’ consisting of SMCs and extracellular matrix that encloses a lipid-rich ‘necrotic core’. Plaques can become increasingly complex, with calcification, ulceration at the luminal surface, and haemorrhage from small vessels that grow into the lesion from the media of the blood vessel wall. Advanced lesions can grow sufficiently large to block blood flow.

The most important clinical complication is an acute occlusion due to the formation of a thrombus or blood clot, resulting in myocardial infarction or stroke. Usually, the thrombus formation (thrombosis) occurs due to rupture or erosion of the lesion.

Read more detail in.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826222/



Atherosclerosis is a pattern of the disease arteriosclerosis, characterized by development of abnormalities called lesions in walls of arteries. These lesions may lead to narrowing of the arterial walls due to buildup of atheromatous plaques.



Ud. 25.6.2024
Pub. 12.6.2024












Arteries in Human Body

 



Abdomen arteries

The abdominal arteries include:


Celiac trunk. Branching off from the abdominal aorta, the celiac trunk divides into smaller arteries that supply organs such as the stomach, liver, and spleen.

Superior mesenteric. Also branching off of the abdominal aorta, it sends blood to the small intestine, pancreas, and most of the large intestine.

Inferior mesenteric. Like the superior mesenteric artery, this artery also branches off of the abdominal aorta and supplies blood to the last portion of the large intestine, which includes the rectum.

Inferior phrenic. These are paired arteries that supply blood to the diaphragm.

Adrenal. The adrenal arteries are paired arteries that send blood to the adrenal glands.

Renal. These paired arteries deliver blood to the kidneys.

Lumbar. These paired arteries send blood to the vertebrae and spinal cord.

Gonadal. The gonadal arteries are paired arteries that send blood to the testes in males and the ovaries in females.

Common iliac. This branch of the abdominal aorta divides into the internal and external iliac arteries.

Internal iliac. Derived from the common iliac artery, this artery supplies blood to the bladder, pelvis, and external portion of the genitals. It also supplies the uterus and vagina in females.

External iliac. Also arising from the common iliac artery, this artery eventually becomes the femoral artery.



Arteries of the legs
Leg arteries include:

Femoral. Derived from the external iliac artery, this artery supplies blood to the thigh and divides into the various smaller arteries that supply the legs.
Genicular. This supplies blood to the knee region.
Popliteal. This is the name given to the femoral artery as it passes below the knee.
Anterior and posterior tibial. Derived from the popliteal artery, these arteries supply blood to the lower portion of the leg. When they reach the ankle, they divide further to supply the ankle and foot region.



https://www.healthline.com/health/arteries-of-the-body 

Monday, June 24, 2024

Lymphoedema - Overview and Bibliography

 


Lymphoedema (LE) is a debilitating condition with the chronic accumulation of interstitial fluid. 1 The permanent pitting stage 2 oedema can evolve into stage 3 non‐pitting oedema with fibrosis and adipose tissue enlargement if remains untreated. Proper control of LE results in ameliorated immune surveillance, less propensity for microbial infections, better function and quality of life. 1 Subsequent to intensive decongestion the application of medical compression stocking (MCS) maintains long‐term volume reduction. 1

ESC Heart Fail. 2021 Oct; 8(5): 4328–4333. Published online 2021 Jul 20. doi: 10.1002/ehf2.13487
PMCID: PMC8497360PMID: 34288554
The effects of lower body compression on left ventricular rotational mechanics in lymphoedema (from the MAGYAR‐Path Study)
Attila Nemes, 1 Árpád Kormányos, 1 Péter Domsik, 1 Anita Kalapos, 1 Lajos Kemény, 2 and Győző Szolnokycorresponding author 2



Overview of the Lymphatic System
ByJames D. Douketis, MD, McMaster University
Reviewed/Revised Apr 2024



Physical treatment for lymphoedema

Process Effect

Exercise Dynamic muscle contractions encourage both passive (movement of lymph along tissue planes and non-contractile lymph vessels) and active (increased contractility of collecting lymph vessels) drainage


Compression (hosiery) Opposes capillary filtration Acts as a counterforce to muscle contractions (so generating greater interstitial pressure changes)

Manual lymphatic drainage Form of massage that stimulates lymph flow in more proximal, normally draining lymphatics to “siphon” lymph from congested areas (particularly trunk)

Multilayer bandaging Used as an intensive treatment in combination with exercise to reduce large, misshapen lower limbs and permit subsequent maintenance treatment with hosiery

Pneumatic compression Softens and reduces limb volume but can forcibly displace fluid into trunk and genitalia. Hosiery must always be worn afterwards

Elevation Does not stimulate lymph drainage but lowers venous pressure and therefore filtration, allowing lymph drainage to catch up






BMJ. 2000 Jun 3; 320(7248): 1527–1529.  doi: 10.1136/bmj.320.7248.1527
PMCID: PMC1118110PMID: 10834903
ABC of arterial and venous disease
Swollen lower limb—2: Lymphoedema
Peter S Mortimer









What are physical treatments for lymphedema?

Lymphedema treatment typically includes a combination of physical therapy and garments or bandaging.  It  moves fluid from areas affected by lymphedema. After physical therapy for lymphedema, it’s very important to use garments or bandaging after therapy to maintain the treatment’s effect. 

Physical treatments for lymphedema. 

Compression garments: Compression garments may be socks, sleeves or wraps that have pressure to move fluid from your tissues into circulation. This reduces swelling. 

Physical therapy: It is a gentle form of massage to stimulate circulation. This is manual lymphatic drainage (MLD). The therapists may teach you how to perform this massage on your own.

Multilayer compression bandaging: If you’ve ever sprained an ankle, you may have put a short stretch bandage on your ankle to keep it from swelling. Multilayer compression bandaging acts the same way on your lymphedema.  The bandages put pressure on your tissues, moving fluid back into circulation.

Compression devices: These pneumatic compression pumps provide on-and-off pressure to keep fluid moving through your lymph vessels and veins so it doesn’t build up in your arms, legs and other parts of your body. The devices work by connecting the pump to a sleeve that wraps around your affected areas. The pump drives a regular cycle of pressure that inflates and deflates the sleeve. Compression pumps may also reduce complications of lymphedema.

Elevation: Gravity plays a role in lymphedema symptoms. You should try to keep the affected area of your body elevated as much as possible.

Exercise: Physical exercise is important to stimulate lymphatic drainage.



Indian J Physiol Pharmacol  . 2002 Jan;46(1):111-4.
Left ventricular function in varicose veins
K Singh, S Sood
PMID: 12024949

Abstract
Left ventricular function (LVF) was evaluated noninvasively by recording systolic time intervals (STIs) in 25 patients suffering from varicose veins (VV) of lower limbs and compared with 25 age--sex matched controls. STI was measured from simultaneous recordings of electrocardiogram (ECG), carotid arterial pulse (CAP) and phonocardiogram (PCG). The left ventricular ejection time (LVET) was significantly shortened with marked increase in pre-ejection period (PEP) and increase in PEP/LVET ratio (P < 0.001) without any variation in electromechanical systoles (QS2) in VV patients compared to controls. These changes in STI suggest contractility of heart is adversely affected in VV patients.




All-Ireland Lymphoedema Guidelines 2022






Oedema Assessment




Love, Lymphedema and Heart Health
BY ARIA HEALTH
FEBRUARY 14, 2023
Lymphedema and the heart are related in several ways. Lymphedema is the swelling of limbs due to a buildup of lymphatic fluid, which can put an increased strain on the heart. This happens because the heart has to work harder to pump blood and circulate it throughout the body, including the affected limb.





Open Access Article
Effect of an Enhanced Self-Care Protocol on Lymphedema Status among People Affected by Moderate to Severe Lower-Limb Lymphedema in Bangladesh, a Cluster Randomized Controlled Trial
by Janet Douglass 1,*ORCID,Hayley Mableson 1,2,Sarah Martindale 1,Sanya Tahmina Jhara 3,Mohammad Jahirul Karim 3,Muhammad Mujibur Rahman 3,Abdullah Al Kawsar 3,Abul Khair 3,ASM Sultan Mahmood 3,AKM Fazlur Rahman 4,Salim Mahmud Chowdhury 4,Susan Kim 5,Hannah Betts 1,Mark Taylor 1 andLouise Kelly-Hope 1
Journals  JCM  Volume 9  Issue 8  10.3390/jcm9082444 


Background: Lymphatic filariasis (LF) is a major cause of lymphedema, affecting over 16 million people globally. A daily, hygiene-centered self-care protocol is recommended and effective in reducing acute attacks caused by secondary infections. It may also reverse lymphedema status in early stages, but less so as lymphedema advances.

This study offers the first evidence for including lymphatic stimulating activities in recommended self-care for people affected by moderate and severe LF-related lymphedema.

Patients and their caregivers are taught the core components of self-care including washing and drying the affected body parts twice per day, attending to entry lesions and interdigital lesions, range of motion exercises, and limb elevation.




Sloan Kettering Institute
Other ways to reduce  risk

Try to avoid crossing your legs as much as possible.
Wear sunscreen with an SPF of 30 or higher to protect your skin from sunburns.
Try to maintain your ideal weight.
Minimize your salt intake. Salt can cause swelling, which may overwhelm your lymphatic system.





Ud. 25.6.2024
Pub. 11.6.2024






















Sunday, June 23, 2024

Diet Break - Diet Restriction for Weight Loss - Full Weight Maintenance Diet in Alternate Periods

 

Weight Loss Strategy of  Taking 2-week Dieting Breaks - Benefits 

If you’re dieting, taking 2 weeks diet breaks  could help you to lose the pounds and keep them off. 

This is the conclusion of a new study. 



Weight loss in body building



Caloric Titration Method works

Lose 1% of the body weight. Maintain the new weight for about a week. This period of weight maintenance allows the individual to eat more or perhaps exercise less than they would while trying to lose weight.

Then achieve another decrease of 1% in body weight, followed by another “break” (weight maintenance). 

Follow this routine until the final weight-loss goal is achieved.

Dr Nicholas Fuller is a Research Fellow at the Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders at the Charles Perkins Centre. 














Wednesday, June 19, 2024

Gastric Secretions - Gastric Fluids Daily Produced

I read somewhere that daily 5 gallons of water is dumped into the intestine. So enquired further.


Daily Fluid Secretion

 Volumes (ml/day) Composition Regulation

Oral secretions

1500 ml

99.8% water; low in sodium

high in calcium and phosphate to help remineralise tooth enamel

Mucin, IgA, amylase, lipase

Stimulated by eating; markedly decreased in patients who are fasted, asleep, sedated or intubated

Oesophageal secretions

Minimal

Thick bicarbonate-rich mucus

Vagal regulation

Gastric acid

2000 ml

Cl- 170mmol/L, K+ 12-20 mmol/L

pH ~ 1.5

Mucus, pepsin, gastric lipase, intrinsic factor

Stimulated by gastrin, histamine, and vagal activity (M3 receptors)

Inhibited by somatostatin, VIP, cholecystokinin and secretin

Bile

600 ml

95% water; concentrated (~ 600 mOsm/kg), alkaline (pH ~ 7.5-8.0)

Bile acids, phospholipids, cholesterol and bilirubin

Secretion is increased by catecholamines, secretin, cholecystokinin, gastrin and glucagon

Release from the gallbladder is mainly mediated by cholecystokinin

Pancreatic exocrine secretions

2500 ml

Isotonic with plasma, but markedly alkaline (pH up to 8.3) 

Cl- 30mmol, HCO3- 140 mmol

Enzymes: lipase, amylase, trypsin, numerous others

Stimulated by vagus,  enteropancreatic reflexes, gastrin, cholecystokinin, and secretin

Inhibited by sympathetic stimulation and somatostatin

Intestinal secretions

2000 ml

Bicarbonate-rich mucus

pH ~ 7.5-8.0

Mainly originating from the duodenum

Stimulated by gastrin, histamine, and vagal activity (M3 receptors)

Inhibited by somatostatin, VIP, cholecystokinin and secretin




https://derangedphysiology.com/main/cicm-primary-exam/required-reading/gastrointestinal-system/Chapter%20110/composition-volumes-and-regulation-gastrointestinal-secretions










Wednesday, June 12, 2024

Lymphedema Massaging Techniques

 


Lymphatic Self Massage - Step 10: Ankle and Foot Technique [Part 18 of 20]

https://www.youtube.com/watch?v=4eOYibT8iP4


Complete Playlist

https://www.youtube.com/watch?v=V0ayXBAXWqI&list=PLWYuRSjQI5zFVs3G8BGTJmU2RdBCnJgHv&index=1



Notes

https://www.uhn.ca/PatientsFamilies/Health_Information/Health_Topics/Documents/How_to_Do_Self_Lymphatic_Massage_Lower_Body.pdf



https://healthcare.msu.edu/_assets/documents/lymphedema/LymphedemaSelfMassageHandout2021_Lower.pdf


Lymphatic Massage


University of Michigan

PDF

A light touch manual therapy technique using different gentle and slow hand movements. ○ Assists the lymphatic system function by promoting lymphangiomotoricty ...

24 pages

https://medicine.umich.edu/sites/default/files/content/downloads/Rogers%20Gina%20December%207%20Lymphatic%20Massage.pdf


Lymphedema Treatment in Physical Therapy


PDH Academy

PDF

Course Abstract. This course refreshes and refines the learner's understanding of lymphedema and lymphedema treatment. It opens with a review of the ...

64 pages

https://pdhacademy.com/wp-content/uploads/2018/08/Lymphedema-COURSE-PDF.pdf