Homeopathy Articles on LinkedIn by Dr.K.S. Gopi

 

https://www.linkedin.com/pulse/hmeopathy-medicines-hypertensionhigh-blood-pressure-dr-ks-gopi/

https://www.linkedin.com/in/dr-ks-gopi-7445291b/

Irritable Bowel Syndrome - Homeopathy

 

https://www.schwabeindia.com/blog/revealed-how-to-treat-irritable-bowel-syndrome-with-homeopathy/

https://www.drhomeo.com/homeopathic-treatment/homeopathic-medicine-for-ibs/

Ayurveda - Websites

 

https://www.eliteayurveda.com/diseases/gastroenteric/lactose-intolerance/

Homeopathy Websites

 

https://www.schwabeindia.com/blog/homeopathy-and-lactose-intolerance/

Ayurveda - Introduction

 https://www.easyayurveda.com/

https://www.easyayurveda.com/2015/08/10/charaka-jwara-chikitsa/

https://www.easyayurveda.com/2015/08/10/charaka-jwara-chikitsa/

https://www.easyayurveda.com/2021/10/28/ahara-shakti-pariksha/

https://www.easyayurveda.com/2021/10/28/vyayama-shakti-pariksha/

https://www.easyayurveda.com/2021/09/02/ushapana/

Charaka Samhita Online

https://www.carakasamhitaonline.com/index.php?title=Main_Page

Contents of Charak Samhita

I. Section on fundamental principles (Sutra Sthana)

II. Section on diagnostic principles (Nidana Sthana)

III. Section on specific medical principles (Vimana Sthana)

IV. Section on human being and genesis (Sharira Sthana)

V. Section on sensorial prognosis (Indriya Sthana)

VI. Section on therapeutic principles (Chikitsa Sthana)

https://www.carakasamhitaonline.com/index.php?title=Rasayana_Adhyaya

VII. Section on pharmaceutical preparations (Kalpa Sthana)

VIII. Section on therapeutic procedures (Siddhi Sthana)

https://www.carakasamhitaonline.com/index.php?title=Sutra_Sthana

Preamble of Sutra Sthana (Section on Fundamental Principles)

From the standpoint of its structure, the Sutra Sthana consists of thirty chapters, grouped into eight logical contexts. The first seven Chatushkas (or tetrads, i.e., groups of four), while the last one is a a group of two chapters (sangrahadvaya).

Matrashiteeya Adhyaya

(Redirected from Matrashiteeya)

 

Sutra Sthana Chapter 5. The proper quantity of food and daily regimen for preserving health

https://www.carakasamhitaonline.com/index.php?title=Matrashiteeya_Adhyaya

Sutra Sthana Chapter 6. Seasonal regimen of diet and lifestyle

This chapter describes seasonal regimen of diet and lifestyle for preservation of health. The year is divided into seasons based upon the changes in environmental conditions, temperature, day-night cycle and circadian rhythm. Being an integral unit of the nature, these seasonal changes in nature affect human physiology too. Therefore, one must follow the specific regimen for maintaining the equilibrium of body components in harmony with nature. The seasonal regimen is designed on the basis of changes in the dosha, bala (strength), and agni (digestive power). This chapter continues the study of dietary regimen from the preceding chapters by adding the dimension of time and seasonal variations to it.

https://www.carakasamhitaonline.com/index.php?title=Tasyashiteeya_Adhyaya

Naveganadharaniya Adhyaya

(Redirected from Naveganadharaniya)

Sutra Sthana Chapter 7. Non-suppressible and suppressible natural urges and other factors for health

https://www.carakasamhitaonline.com/index.php?title=Naveganadharaniya_Adhyaya

Indriyopakramaniya Adhyaya

(Redirected from Indriyopakramaniya)

Sutra Sthana Chapter 8.The Disciplinary Protocol for Sense and Motor Organs

https://www.carakasamhitaonline.com/index.php?title=Indriyopakramaniya_Adhyaya

Section/Chapter Chikitsa Sthana Section 6/

Chikitsa Sthana

Preamble of Chikitsa Sthana

Chikitsa Sthana deals with the study of preservation of health, prevention and management of various diseases.

https://www.carakasamhitaonline.com/mediawiki-1.32.1/index.php?title=Chikitsa_Sthana

https://www.carakasamhitaonline.com/index.php?title=Vajikarana_Adhyaya

----------------------

https://www.eliteayurveda.com/diseases/gastroenteric/lactose-intolerance/

Ud. 14.4.2022

Pub 11.12.2021

Action on High Salt Intake

 

https://www.actiononsalt.org.uk/about/

Action on Salt was set up in 1996.

The current target is to reduce salt intake to an average of 6g a day for adults and even less for children, from the current average of 8.1g a day.   This reduction will have a large impact on reducing strokes by approximately 22% and heart attacks by 16% saving 17,000 lives in the UK as well as other health benefits for the population.

https://www.dailyrecord.co.uk/lifestyle/health-fitness/what-salt-really-your-body-27299005

Collateral Arteries - Arteriogenesis

  

Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease 

Niels van Royen, Jan J. Piek, Ivo Buschmann, Imo Hoefer, Michiel Voskuil, Wolfgang Schaper Author Notes

Cardiovascular Research, Volume 49, Issue 3, February 2001, Pages 543–553, https://doi.org/10.1016/S0008-6363(00)00206-6

https://academic.oup.com/cardiovascres/article/49/3/543/308560

Pentoxifylline - Trental 400

Pentoxifylline for vascular health: a brief review of the literature.

McCarty MF1, O'Keefe JH2, DiNicolantonio JJ2

Author information

Open Heart, 08 Feb 2016, 3(1):e000365

DOI: 10.1136/openhrt-2015-000365 PMID: 26870389 PMCID: PMC4746528 

https://europepmc.org/article/pmc/4746528

Pentoxifylline: A Drug with Antiviral and Anti-Inflammatory Effects to Be Considered in the Treatment of Coronavirus Disease 2019

Ghasemnejad-Berenji M.a · Pashapour S.b · Sadeghpour S.c

Author affiliations

Corresponding Author

Keywords: Severe acute respiratory syndrome coronavirus-2Coronavirus disease 2019Pentoxifylline

Med Princ Pract 2021;30:98–100

https://doi.org/10.1159/000512234

https://www.karger.com/Article/FullText/512234

A Combined Treatment Effect of Cilostazol and Pentoxifylline in the Treatment of Peripheral Vascular Disease

Jalpa Suthar   Birju Shah  Ritu Ranjan

Asian Journal of Medicine and Health, Page 74-80

DOI: 10.9734/ajmah/2022/v20i1130528

Published: 3 September 2022

https://journalajmah.com/index.php/AJMAH/article/view/731

The rest pain: Out of 52 patients, 42 (80.7%)  showed improvement in six months.

For intermediate claudication 73% patients showed improvement in six months.

Zilast (Cilostazeol)

Trental, Kinetal (Pentoxifylline)

Ud 20.10.2022

pub 10.9.2022

Peripheral Artery Disease (PAD) - Severe Limb Ischemia

 

Peripheral Artery Disease

Emile R. Mohler, Michael R. Jaff

John Wiley & Sons, 13-Jul-2017 - Medical - 208 pages

A comprehensive, quick-reference guide to the diagnosis and management of peripheral artery disease for non-specialists

With an aging population subject to an increasing number of health risks, peripheral artery disease (PAD) is on the rise throughout the world. Because of PAD's direct links to heart attack and stroke, it is critical that internists, surgeons, cardiologists, radiologists, gerontologists, GPs, and family practitioners know how to recognize it and make the best treatment recommendations for their patients. This book provides all the expert, practical information and guidance they need to do just that.

Edited by two thought leaders in PAD diagnosis and treatment, and comprising chapters written by subject matter experts, Peripheral Artery Disease, Second Edition provides clinicians with guidance on how to diagnose and treat one of the most under-diagnosed conditions affecting millions of patients. This updated and revised edition of the popular guide distills the complexities of PAD into clear, actionable advice for busy medical practitioners, providing them with the information they need—when they need it.

Provides clinicians with essential information for recognizing and treating this under-diagnosed condition that affects millions of patients

Distills the complexities of PAD, from diagnosis to traditional and emerging treatment options, into clear, actionable advice for clinicians

Covers PAD epidemiology, office examination, imaging, laboratory evaluation, medical therapy, surgical interventions, endovascular treatments, and much more

Reflects the latest PAD Guidelines and Performance Measures established by leading specialty societies

Features contributions from internists and surgeons, all recognized experts in PAD

Peripheral Artery Disease, Second Edition is an important working reference for internists, cardiologists, radiologists, and surgeons, as well as fellows and residents in those fields.

https://books.google.co.in/books?id=3uEsDwAAQBAJ

LOWER EXTREMITY MANIFESTATIONS OF PERIPHERAL ARTERY DISEASE: THE PATHOPHYSIOLOGIC AND FUNCTIONAL IMPLICATIONS OF LEG ISCHEMIA

Circ Res. Author manuscript; available in PMC 2016 Apr 24.Published in final edited form as:Circ Res. 2015 Apr 24; 116(9): 1540–1550.  doi: 10.1161/CIRCRESAHA.114.303517

PMCID: PMC4410164NIHMSID: NIHMS676651PMID: 25908727

Mary McGrae McDermott, MD

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410164/

Diagnosis and Treatment of Chronic Arterial Insufficiency of the Lower Extremities: A Critical Review

Jeffrey I. Weitz, John Byrne, G. Patrick Clagett, Michael E. Farkouh, 

Originally published1 Dec 1996https://doi.org/10.1161/01.CIR.94.11.3026Circulation. 1996;94:3026–3049

https://www.ahajournals.org/doi/full/10.1161/01.cir.94.11.3026

What is critical limb ischemia?

Critical limb ischemia (CLI) is a severe blockage in the arteries of the lower extremities, which markedly reduces blood-flow. It is a serious form of peripheral arterial disease, or PAD, but less common than claudication. PAD is caused by atherosclerosis, the hardening and narrowing of the arteries over time due to the buildup of fatty deposits called plaque.

CLI is a chronic condition that results in severe pain in the feet or toes, even while resting. Complications of poor circulation can include sores and wounds that won't heal in the legs and feet. Left untreated, the complications of CLI will result in amputation of the affected limb.

Symptoms of critical limb ischemia

The most prominent features of critical limb ischemia are called ischemic rest pain — severe pain in the legs and feet while a person is not moving, or non-healing sores on the feet or legs. Other symptoms include:

Pain or numbness in the feet

Shiny, smooth, dry skin of the legs or feet

Thickening of the toenails

Absent or diminished pulse in the legs or feet

Open sores, skin infections or ulcers that will not heal

Dry gangrene (dry, black skin) of the legs or feet

https://health.ucdavis.edu/vascular/diseases/cli.html

Critical limb ischemia: current challenges and future prospects

Vasc Health Risk Manag. 2018; 14: 63–74. Published online 2018 Apr 26. doi: 10.2147/VHRM.S125065

PMCID: PMC5927064PMID: 29731636

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927064/

Dyslipidemia

Total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides and lipoprotein(s) are risk factors for development and progression of PAD.24 The use of statins in PAD patients is recommended. It is well documented that low levels of LDL-C reduce cardiovascular events (myocardial infarction, cerebrovascular events), and the goal in all patients with PAD is LDL-C <70 mg/dL.

Hypertension

Guidelines suggest a close control of blood pressure with values <140/90 mmHg in all patients and <130/80 mmHg in diabetic patients or patients with proteinuria. All drugs that are effective in lowering blood pressure can be used: thiazide diuretics, angiotensin-converting enzymes (ACEs), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs) and beta-adrenergic blockers. In diabetic patients, ACE and ARB are considered as the first-line treatment.

https://en.wikipedia.org/wiki/Chronic_limb_threatening_ischemia

Peripheral arterial disease and critical limb ischaemia: still poor outcomes and lack of guideline adherence

European Heart Journal, Volume 36, Issue 15, 14 April 2015, Pages 932–938, https://doi.org/10.1093/eurheartj/ehv006

https://academic.oup.com/eurheartj/article/36/15/932/2293203

Lower limb ischaemia

EBM Guidelines

7.7.2020

Palpation for foot pulses

First-line examination. The arteries to palpate are the dorsalis pedis artery and the posterior tibial artery.

Oedema will hamper the palpation.

The examiner’s own capillary pulse may interfere with the palpation.

If both the dorsalis pedis artery and the posterior tibial artery can definitely be palpated, significant arterial stenosis is improbable. An inconclusive finding is always an indication for a Doppler study.

The efficacy of pentoxiphylline has not been established. The clinical response is either of short duration, slight or insignificant.

A selective beta-blocker may usually be used with no adverse effects, unless the patient has critical ischaemia. A beta-blocker may be indicated for the treatment of coronary heart disease or hypertension.

https://www.ebm-guidelines.com/ebmg/ltk.free?p_artikkeli=ebm00101

EXERCISE REHABILITATION FOR PERIPHERAL ARTERY DISEASE: A REVIEW

Mary M. McDermott, MD

J Cardiopulm Rehabil Prev. Author manuscript; available in PMC 2019 Mar 1.Published in final edited form as:J Cardiopulm Rehabil Prev. 2018 Mar; 38(2): 63–69.  doi: 10.1097/HCR.0000000000000343

PMCID: PMC5831500NIHMSID: NIHMS932613PMID: 29465495

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831500/

Google search  "walking exercise peripheral arterial disease"

Low-Intensity vs High-Intensity Walking Exercise and Walk Distance in Patients With Peripheral Artery Disease

Original Investigation, April 6, 2021

Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease

The LITE Randomized Clinical Trial

Mary M. McDermott, et al.

JAMA. 2021;325(13):1266-1276. doi:10.1001/jama.2021.2536

Key Points

Question  Does a low-intensity (does not induce ischemic leg symptoms) home-based walking exercise intervention improve 6-minute walk distance more than a high-intensity (induces ischemic leg symptoms) home-based walking exercise intervention and does the low-intensity intervention improve 6-minute walk distance more than a nonexercise control (weekly health educational sessions only) among patients with lower-extremity peripheral artery disease (PAD)?

Findings  Low-intensity exercise, high-intensity exercise, and nonexercise control resulted in a mean 12-month change in 6-minute walk distance of −6.4 m, 34.5 m, and −15.1 m, respectively. Low-intensity exercise was significantly less effective than high-intensity exercise and was not significantly different from the nonexercise control.

Meaning  These findings do not support the use of low-intensity walking exercise for patients with PAD.

Design, Setting, and Participants  Multicenter randomized clinical trial conducted at 4 US centers and including 305 participants. Enrollment occurred between September 25, 2015, and December 11, 2019; final follow-up was October 7, 2020.

Interventions  Participants with PAD were randomized to low-intensity walking exercise (n = 116), high-intensity walking exercise (n = 124), or nonexercise control (n = 65) for 12 months. Both exercise groups were asked to walk for exercise in an unsupervised setting 5 times per week for up to 50 minutes per session wearing an accelerometer to document exercise intensity and time. The low-intensity group walked at a pace without ischemic leg symptoms. The high-intensity group walked at a pace eliciting moderate to severe ischemic leg symptoms. Accelerometer data were viewable to a coach who telephoned participants weekly for 12 months and helped them adhere to their prescribed exercise. The nonexercise control group received weekly educational telephone calls for 12 months.

Results  

Among 305 randomized patients (mean age, 69.3 [SD, 9.5] years, 146 [47.9%] women, 181 [59.3%] Black patients), 250 (82%) completed 12-month follow-up. 

The 6-minute walk distance changed from 332.1 m at baseline to 327.5 m at 12-month follow-up in the low-intensity exercise group (within-group mean change, −6.4 m [95% CI, −21.5 to 8.8 m]; P = .34) 

From 338.1 m to 371.2 m in the high-intensity exercise group (within-group mean change, 34.5 m [95% CI, 20.1 to 48.9 m]; P < .001) and the mean change for the between-group comparison was −40.9 m (97.5% CI, −61.7 to −20.0 m; P < .001). 

The 6-minute walk distance changed from 328.1 m at baseline to 317.5 m at 12-month follow-up in the nonexercise control group (within-group mean change, −15.1 m [95% CI, −35.8 to 5.7 m]; P = .10), which was not significantly different from the change in the low-intensity exercise group (between-group mean change, 8.7 m [97.5% CI, −17.0 to 34.4 m]; P = .44).

https://jamanetwork.com/journals/jama/fullarticle/2778112

Editorial

April 12, 2022

Home-Based Walking Exercise for Peripheral Artery Disease

Mary M. McDermott, MD1,2

Author Affiliations

JAMA. 2022;327(14):1339-1340. doi:10.1001/jama.2022.2457

https://jamanetwork.com/journals/jama/article-abstract/2790952

Pentoxifylline for vascular health: a brief review of the literature 

Mark F McCarty1, James H O'Keefe2 and James J DiNicolantonio2

https://openheart.bmj.com/content/3/1/e000365

Us. 19.10.2022

Pub. 17.9.2022

Reduction of LDL Cholesterol

 Studies have found that if the LDL cholesterol is reduced to less than 70 mg/dL and preferably less than 55 mg/dL, the size of the plaques can get smaller.19-Jul-2021

https://www.uptodate.com/contents/high-cholesterol-and-lipid-treatment-options-beyond-the-basics

Safety and Efficacy of Extremely Low LDL-Cholesterol Levels and Its Prospects in Hyperlipidemia Management

Dhrubajyoti Bandyopadhyay,corresponding author 1 Arshna Qureshi, 2 Sudeshna Ghosh, 3 Kumar Ashish, 4 Lyndsey R. Heise, 5 Adrija Hajra, 6 and Raktim K. Ghosh 7

J Lipids. 2018; 2018: 8598054. Published online 2018 Apr 23. doi: 10.1155/2018/8598054

PMCID: PMC5937425PMID: 29850255

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937425/

PCSK9 Therapies

Inclisiran from Novartis

Inclisiran - It Was To Be The Cholesterol Drug For The Masses. Novartis Changed That.

John LaMattinaContributor

I cover news on drugs and R&D in the pharma industry

Jan 3, 2022,

https://www.forbes.com/sites/johnlamattina/2022/01/03/it-was-to-be-the-cholesterol-drug-for-the-masses-novartis-changed-that/ 

Two PCSK9 antibodies were approved by the FDA in 2015: Praluent (Sanofi/Regeneron) and Repatha (Amgen). Unfortunately, the list prices of these much anticipated drugs were initially set at a jaw dropping $14,000/year/patient.

in 2018 first Amgen, then Sanofi/Regeneron lowered the list prices to $5,850, hoping that higher sales would ensue. 

In India, Price on 26.9.2022

Repatha Sure Click Evolocumab 140mg Mg Solution For Injection in Prefilled Syringe

₹ 19,500/ PIECE

Usage/Application: Personal

size: 1 PREFILLED PEN DEVICE(s)

Treatment: Heart disorders

Manufacturer: DR REDDY'S LABORATORIES LTD

Strength: 140mg

Brand: EVOLOCUMAB

(Two injections per month are needed.)

Arterial Stiffness - Mechanism of Development and Its Reduction

 Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness

Susan J. Zieman, Vojtech Melenovsky and David A. Kass

Originally published24 Feb 2005https://doi.org/10.1161/01.ATV.0000160548.78317.29Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:932–943

https://www.ahajournals.org/doi/10.1161/01.atv.0000160548.78317.29

Diurnal Blood Pressure Variation

 Diurnal blood pressure variation and related behavioral factors

Yuhei Kawano 

Hypertension Research volume 34, pages281–285 (2011)

https://www.nature.com/articles/hr2010241

Cilnidipine - Use and Benefits

 

Patent - New use of cilnidipine

https://patents.google.com/patent/CN102416013A/en

Cholesterol and Triglycerides - Information

High cholesterol in legs - Symptoms

https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/high-cholesterol-signs-of-dangerously-high-cholesterol-levels-present-in-your-legs/photostory/86712234.cms  

Reduction of LDL Cholesterol by 25% to 60% in Patients With Primary Hypercholesterolemia by Atorvastatin, a New HMG-CoA Reductase Inhibitor.

James W. Nawrocki, Stuart R. Weiss, Michael H. Davidson, Dennis L. Sprecher, Sherwyn L. Schwartz, Paul-J. Lupien, Peter H. Jones, Harry E. Haber and Donald M. Black.

Originally published1 May 1995https://doi.org/10.1161/01.ATV.15.5.678Arteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:678–682

Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 15, No. 5

https://www.ahajournals.org/doi/full/10.1161/01.atv.15.5.678

Rosuvastatin for lowering lipids

50% reduction in LDL is reported in multiple studies.

Stephen P Adams, Sarpreet S Sekhon, and James M Wrightcorresponding author

Cochrane Database Syst Rev. 2014 Nov; 2014(11): CD010254. Published online 2014 Nov 21.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463960/

Who Needs Cholesterol-lowering Medicine

Your treatment plan for high cholesterol will depend on your current cholesterol levels and your risk of heart disease and stroke. Your risk for heart disease and stroke depends on other risk factors, including high blood pressure and high blood pressure treatment, smoking status, age, high-density lipoprotein cholesterol level, total cholesterol level, diabetes, family history, and whether you have already had a heart attack or stroke.

Your health care provider may prescribe medicine if:

You have already had a heart attack or stroke, or you have peripheral arterial disease.

Your LDL cholesterol level is 190 mg/dL or higher.

You are 40–75 years old with diabetes and an LDL cholesterol level of 70 mg/dL or higher.

You are 40–75 years old with a high risk of developing heart disease or stroke and an LDL cholesterol level of 70 mg/dL or higher.

https://www.cdc.gov/cholesterol/treating_cholesterol.htm

Efficacy of alternate day versus everyday dosing of rosuvastatin in hyperlipidemia.

Alternate day gives same effect as daily dose

Chandrashekar Panchavarthi, Ushasree Takkela Shankara, Vijayakrishna Pakanati, Shirisha Siddamshetty, Jaya Prakash Konda, Sai kumar Gowlikar

https://dx.doi.org/10.18203/2319-2003.ijbcp20163234

Published: 2017-01-10

https://www.ijbcp.com/index.php/ijbcp/article/view/635

Fat Cells

https://en.wikipedia.org/wiki/Adipocyte

https://journals.physiology.org/doi/full/10.1152/ajpregu.00257.2017

Ud. 24.9.2022

Pub 5.10.2021

Abdominal Angina

 

Abdominal Angina

Kunal Mahajan; Azeberoje Osueni; Muhammad Haseeb.

Abdominal angina is postprandial pain that occurs in mesenteric vascular occlusive disease when blood flow to the colon is unable to meet visceral demands. This is similar to intermittent claudication in peripheral vascular disease or angina pectoris in coronary artery disease. 

Atherosclerotic disease is the most common cause of abdominal angina.  In most people, it is occlusion of the superior mesenteric artery that is responsible for the abdominal symptoms.

Shortly after eating, patients with abdominal angina are unable to increase flow in the mesenteric vessels, and they develop pain.

Author Information

Last Update: May 23, 2022.

https://www.ncbi.nlm.nih.gov/books/NBK441943/

Mesenteric artery disease

https://academic.oup.com/eurheartj/article/39/9/763/4095038

https://www.bcm.edu/healthcare/specialties/cardiovascular-medicine/vascular-health/mesenteric-artery-disease

Mesenteric artery stenosis

Debabrata Mukherjee and Leslie Cho.

https://www.ncbi.nlm.nih.gov/books/NBK27423/

Chronic Mesenteric Ischemia: Diagnosis and Treatment

Eric J. Hohenwalter, M.D.1

Semin Intervent Radiol. 2009 Dec; 26(4): 345–351.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036470/

Mesenteric Artery Ischemia

Alin Gragossian; Maxim E. Shaydakov; Patrick Dacquel.

Author Information

Last Update: May 9, 2022.

https://www.ncbi.nlm.nih.gov/books/NBK513354/

Chronic Mesenteric Ischemia

Ronak Patel; Abdul Waheed; Michael Costanza.

Author Information

Last Update: July 12, 2022.

Mesenteric ischemia is a manifestation of peripheral vascular disease in which the blood supply fails to meet the metabolic demands of visceral organs.

Mesenteric artery stenosis is relatively common, occurring in up to 10% of the population over 65 years of age. However, CMI has a very low incidence, accounting for less than 1 in 1000 hospital admissions for abdominal pain. Patients are typically between the ages of 50 and 70 years of age, with a strong female predominance, and have other coexisting manifestations of atherosclerotic disease.

Indications for Surgery

Signs of peritonitis on physical exam

Massive lower GI hemorrhage

Ongoing signs of abdominal pain, fever, or  sepsis

Symptoms that have persisted for more than 14 to 21 days

Chronic malabsorption leading to protein-losing colopathy

Colonoscopic evidence of segmental colitis with frank ulceration

Presence of an ischemic stricture and abdominal symptoms

https://www.ncbi.nlm.nih.gov/books/NBK430748/

Stroke - Treatment and Prevention with Homeopathy

 Stroke - Treatment and prevention with Homeopathy and Schuessler salts (homeopathic cell salts): A homeopathic and naturopathic guide

Robert Kopf

BookRix, 14-Jul-2018 - Health & Fitness - 52 pages

A stroke occurs when the blood supply to part of the brain is interrupted or severely reduced, depriving brain tissue of oxygen and glucose. Stroke is also referred to as cerebrovascular accident. Within minutes, brain cells begin to die.

Signs and symptoms of stroke include sudden dizziness, loss of balance and coordination, trouble with speaking and understanding, difficulty with eating and swallowing, confusion, sudden and severe headache, vomiting, altered consciousness and sudden tingling, weakness, paralysis or numbness of the face, arm or leg especially on one side of the body.

In this naturopathic adviser, I will give you recommendations how to prevent a stroke and support the treatment with Homeopathy, Schuessler salts (also named cell salts, tissue salts) and herbal tinctures. I will present you the most proven homeopathic remedies and Schuessler salts, including the appropriate potency and dosage. I wish you much success, joy of life and especially your health.

https://books.google.co.in/books?id=IVXgAgAAQBAJ

Increase in Blood Viscosity - Complications

 

https://www.nature.com/articles/hr2012172

Blood Rheology: Key Parameters, Impact on Blood Flow, Role in Sickle Cell Disease and Effects of Exercise

2019

https://www.frontiersin.org/articles/10.3389/fphys.2019.01329/full

All you need to know about thick blood

https://www.medicalnewstoday.com/articles/319842 

Blood viscosity and blood pressure: role of temperature and hyperglycemia 

Yildirim Çinar, A. Mete Şenyol, Kamber Duman

American Journal of Hypertension, Volume 14, Issue 5, May 2001, Pages 433–438,

https://academic.oup.com/ajh/article/14/5/433/205476

https://www.encyclopedia.com/medicine/encyclopedias-almanacs-transcripts-and-maps/blood-viscosity-reducing-drugs

Steep rise in cases of arterial thrombosis in post-Covid patients, say doctors

"Don't take severe leg pain or any abnormal changes in the body casually, especially during the post-Covid period," said a doctor

By: Lifestyle Desk

New Delhi | August 20, 2021 9:10:47 am

https://indianexpress.com/article/lifestyle/health/arterial-thrombosis-blood-clots-gangrene-amputation-post-covid-patients-doctors-symptoms-treatment-7460872/

POST-THROMBOTIC SYNDROME

Last updated June 29, 2022

Venous Stress Disorder

An In-Depth Guide for Patients and Health Care Providers

Compression socks

https://www.stoptheclot.org/postthrombotic-syndrome/

https://courses.lumenlearning.com/suny-ap2/chapter/blood-flow-blood-pressure-and-resistance-no-content/    Lot details

https://www.cureus.com/articles/27906-the-role-of-blood-viscosity-in-infectious-diseases

Pharmacology in Rehabilitation, Updated 5th Edition

Front Cover

Charles D. Ciccone

F.A. Davis, 24-Jan-2022 - Medical - 720 pages

Drugs - Pentoxifylline

https://books.google.co.in/books?id=vwFgEAAAQBAJ&pg=PT782#v=onepage&q&f=false

Clinical Aspects of Blood Viscosity and Cell Deformability

G. D. O. Lowe, J. C. Barbenel, C. D. Forbes

Springer Science & Business Media, 06-Dec-2012 - Medical - 262 pages

After many years of relative neglect, the importance of study of factors governing blood flow has at last achieved recognition; in this volume are documented many of the techniques, and the basic scientific and clinical observations, which have helped to open up understanding of this highly important aspect of human physiology and pathology in recent years. The text is logically divided into five sections beginning with blood cell deformability, then moving on to theoretical consideration of blood rheology, followed by accounts of the interrelationships between rheology, blood flow and vascular occlusion. The final two sections deal with blood rheology in clinical practice and therapeutic aspects of the study of blood flow. As regards blood cell deformability (Section A), the basic problem is set out by Kiesewetter and colleagues in the first paragraph of chapter 1 (p. 3), in which they point out that whereas human erythrocytes at rest have a diameter of approxi mately 7. 5 /-tm, nutritive capillaries have diameters ranging from 3-5 /-tm, and chapters in section A give an account of the ways in which the red cell can undergo deformation to permit capillary perfusion and the maintenance of the microcirculation.

Effects on Blood Flow

https://books.google.co.in/books?id=ePcqBgAAQBAJ&pg=PA243#v=onepage&q&f=false

Exercise Testing and Exercise Prescription for Special Cases: Theoretical Basis and Clinical Application

James S. Skinner

Lippincott Williams & Wilkins, 2005 - Medical - 418 pages

This text discusses how theoretical and applied aspects of exercise testing and exercise prescription must be modified due to the restrictions and/or limitations created by a specific health state. Topics covered include: general principles of exercise testing and exercise prescription; discussion of the importance of such general factors as age, gender, and environment; specific health states, general treatment, risk factors, how it may affect and be affected by exercise; how to modify exercise testing procedures; how to prescribe exercise; and the effects from exercise programs.

Exercise Issues for Claudication

https://books.google.co.in/books?id=zNr9j6g9GHAC&pg=PA319&lpg=PA319#v=onepage&q&f=false

Mango Kernel - Benefits - Mango Seed

 

https://www.healthbenefitstimes.com/mango-seed/

https://www.dnaindia.com/ahmedabad/report-nutrient-rich-gutli-is-the-hero-in-mango-tale-researchers-2608398

https://www.linkedin.com/pulse/mango-seed-kernel-highly-nutritious-food-chemicals-should-patel/

Telugu

https://telugu.samayam.com/lifestyle/health/health-benefits-of-mango-kernels/articleshow/91180003.cms

Muscle Cramps

 

Foods That May Help With Muscle Cramps

 Medically Reviewed by Poonam Sachdev on March 06, 2022

https://www.webmd.com/pain-management/ss/slideshow-muscle-cramps-foods

Are cramps caused by lack of salt?

By Claudia Hammond

1st May 2012

This common affliction has often been ascribed to low salt levels in your diet, but what causes these painful aches is still a mystery.

https://www.bbc.com/future/article/20120430-are-cramps-due-to-lack-of-salt

Immunotherapy

Immunotherapy to Treat Cancer

Immunotherapy is a type of cancer treatment that helps your immune system fight cancer. The immune system helps your body fight infections and other diseases. It is made up of white blood cells and organs and tissues of the lymph system.

Immunotherapy is a type of biological therapy. Biological therapy is a type of treatment that uses substances made from living organisms to treat cancer.

2019

https://www.cancer.gov/about-cancer/treatment/types/immunotherapy

Chemotherapy and immunotherapy (atezolizumab).

Chemotherapy

In women with metastatic breast cancer that is hormone receptor negative, has not responded to hormone therapy, has spread to other organs or has caused symptoms, treatment may include:

Chemotherapy with one or more drugs.

Chemotherapy and immunotherapy

In women with metastatic breast cancer that is hormone receptor negative and HER2 negative, treatment may include:

Chemotherapy and immunotherapy (atezolizumab).

https://www.cancer.gov/types/breast/patient/breast-treatment-pdq#_707

https://onlinelearning.hms.harvard.edu/hmx/immunity/

https://www.allergy.org.au/patients/immunodeficiencies/covid-19-and-immunodeficiency

https://www.dw.com/en/the-immune-systems-fight-against-the-coronavirus/a-53048894

https://www.frontiersin.org/subjects/coronavirus


The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The experience of clinical immunologists from China
Wen Zhang, Yan Zhao, [...], and Shuyang Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102614/

ud. 17.9.2022

pub. 13.4.2020

Congestive Heart Failure

 

Congestive Heart Failure (CHF)

https://www.healthline.com/health/congestive-heart-failure

Congestive Heart Failure Diet: How to Reduce Fluid

https://www.healthline.com/health/congestive-heart-failure-diet

Stents - Different Varieties

 September 12, 2022

Optimed’s Tentos 4-F Stent System Launched in Europe

    

September 12, 2022—Optimed,  Germany, announced the launch of the Tentos 4-F self-expanding stent system for the treatment of superficial femoral and infrapopliteal arteries. It is now commercially available. According to the company, the Tentos stent is offered in diameters of 3 to 8 mm and is compatible with 0.018-inch guidewires. The delivery system features a low crossing profile and is compatible with all 4-F sheaths. The Tentos stent is designed with thinner struts and shorter stent rings and provides tighter stent wall apposition compared to conventional superficial femoral artery stents. The Tentos system also has enhanced vessel coverage, conformability, and visibility compared to Optimed’s current 4-F stent system. 

https://evtoday.com/news/optimeds-tentos-4-f-stent-system-launched-in-europe-and-other-ce-mark-countries

PURE - Cardiovascular Diseases Studies - Publications

 

2017

https://www.thelancet.com/article/S0140-6736(17)32252-3/fulltext

2022

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01441-6/fulltext

https://www.thehindu.com/sci-tech/health/similar-strategies-required-to-handle-cardiovascular-disease-in-men-and-women-lancet-study/article65875126.ece

Pure Diet score

https://ipccs.org/2018/09/04/higher-healthy-diet-score-reduced-cv-disease-and-mortality-worldwide/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435701/

WHO guidelines on foods

https://www.who.int/news-room/fact-sheets/detail/healthy-diet

Practical advice on maintaining a healthy diet

Fruit and vegetables

Eating at least 400 g, or five portions, of fruit and vegetables per day reduces the risk of NCDs (2) and helps to ensure an adequate daily intake of dietary fibre.

Fruit and vegetable intake can be improved by:

always including vegetables in meals;

eating fresh fruit and raw vegetables as snacks;

eating fresh fruit and vegetables that are in season; and

eating a variety of fruit and vegetables.

Fats

Reducing the amount of total fat intake to less than 30% of total energy intake helps to prevent unhealthy weight gain in the adult population (1, 2, 3). Also, the risk of developing NCDs is lowered by:

reducing saturated fats to less than 10% of total energy intake;

reducing trans-fats to less than 1% of total energy intake; and

replacing both saturated fats and trans-fats with unsaturated fats (2, 3) – in particular, with polyunsaturated fats.

Fat intake, especially saturated fat and industrially-produced trans-fat intake, can be reduced by:

steaming or boiling instead of frying when cooking;

replacing butter, lard and ghee with oils rich in polyunsaturated fats, such as soybean, canola (rapeseed), corn, safflower and sunflower oils;

eating reduced-fat dairy foods and lean meats, or trimming visible fat from meat; and

limiting the consumption of baked and fried foods, and pre-packaged snacks and foods (e.g. doughnuts, cakes, pies, cookies, biscuits and wafers) that contain industrially-produced trans-fats.

Salt, sodium and potassium

Most people consume too much sodium through salt (corresponding to consuming an average of 9–12 g of salt per day) and not enough potassium (less than 3.5 g). High sodium intake and insufficient potassium intake contribute to high blood pressure, which in turn increases the risk of heart disease and stroke (8, 11).

Reducing salt intake to the recommended level of less than 5 g per day could prevent 1.7 million deaths each year (12).

People are often unaware of the amount of salt they consume. In many countries, most salt  comes from processed foods (e.g. ready meals; processed meats such as bacon, ham and salami; cheese; and salty snacks) or from foods consumed frequently in large amounts (e.g. bread). Salt is also added to foods during cooking (e.g. bouillon, stock cubes, soy sauce and fish sauce) or at the point of consumption (e.g. table salt).

Salt intake can be reduced by:

limiting the amount of salt and high-sodium condiments (e.g. soy sauce, fish sauce and bouillon) when cooking and preparing foods;

not having salt or high-sodium sauces on the table;

limiting the consumption of salty snacks; and

choosing products with lower sodium content.

Some food manufacturers are reformulating recipes to reduce the sodium content of their products, and people should be encouraged to check nutrition labels to see how much sodium is in a product before purchasing or consuming it.

Potassium can mitigate the negative effects of elevated sodium consumption on blood pressure. Intake of potassium can be increased by consuming fresh fruit and vegetables.

Sugars

In both adults and children, the intake of free sugars should be reduced to less than 10% of total energy intake (2, 7).  A reduction to less than 5% of total energy intake would provide additional health benefits (7).

Consuming free sugars increases the risk of dental caries (tooth decay). Excess calories from foods and drinks high in free sugars also contribute to unhealthy weight gain, which can lead to overweight and obesity. Recent evidence also shows that free sugars influence blood pressure and serum lipids, and suggests that a reduction in free sugars intake reduces risk factors for cardiovascular diseases (13).

Sugars intake can be reduced by:

limiting the consumption of foods and drinks containing high amounts of sugars, such as sugary snacks, candies and sugar-sweetened beverages (i.e. all types of beverages containing free sugars – these include carbonated or non‐carbonated soft drinks, fruit or vegetable juices and drinks, liquid and powder concentrates, flavoured water, energy and sports drinks, ready‐to‐drink tea, ready‐to‐drink coffee and flavoured milk drinks); and

eating fresh fruit and raw vegetables as snacks instead of sugary snacks.

Weight Gain in Summer

 

In the summer, body weight can go up by several pounds due to increased body water. This is accomplished through fluid-conserving hormones such as aldosterone, which allows the kidney to retain more fluid and reduces the amount of salt in sweat, a measure that also aids in water retention. The increase and stabilization of total body water can only be accomplished by continuing to exercise in hot weather and will not occur in people who spend most of their time indoors in air-conditioned environments.

https://www.scientificamerican.com/article/experts-body-wieght-ambient-temperature/

https://timesofindia.indiatimes.com/life-style/health-fitness/weight-loss/weight-loss-ways-water-could-be-making-you-gain-weight/photostory/78020546.cms

https://www.fatherly.com/health-science/why-am-i-gaining-weight-summer-fat/

12 Tissue Remedies - ENT Diseases

 

https://archive.org/stream/twelvetissuerem00boer/twelvetissuerem00boer_djvu.txt

https://californiahomeopath.com/about-the-journal/

CALCAREA FLUOR1CA. 

Synonyms. — Calcii Fluoridum. Calcium Fluoride. Cal- carea Fluorata. 

Common Name. — Fluorspar. Fluoride of Lime. 

Page 37

Ears. — Calcareous deposits on the tympani. Mastoid disease when periosteum is affected. 

Nose. — Cold in the head, ineffectual desire to sneeze, stuffy cold, dry coryza, ozsena. Copious, offensive, thick, greenish, lumpy, yellow nasal discharge. Osseous growths. Affections of nasal bones ; odor of dead bone disappears after use of the remedy. Adenoid growths in post-nasal space and pharynx. 

Face. — Hard swelling on the cheek with pain or toothache, hard swelling on the jawbone, cold sores rather small, hard herpetic sores on lips from cold, not diffused like Natr. mur. 

Mouth. — Gumboil with hard swelling on the jaw, stony hard swelling on the jawbone. Cold sores at corner of mouth. Great dryness of mouth. 

Tongue. — Cracked appearance of the tongue with or with- out pain. Induration of the tongue, hardening after inflammation. 

Teeth. — Enamel of the teeth rough and deficient. Unnatural looseness of the teeth with or without pain, teeth become loose in their sockets. Malnutrition of the teeth. Toothache with pain if any food touches the tooth. Tooth- ache with a looseness of the teeth. 

Throat. — Diphtheria when the affection has gone to the windpipe. Relaxed throat with tickling in the larynx when caused by elongation of the uvula. Uvula relaxed, causing irritation, tickling and cough. Hawking of mucus in the morning. Burning in throat better by warm drinks. Great dryness of throat 

Hypothyroid and Homeopathy

 

Thyroid Problems and Diseases

https://www.askdrshah.com/app/underactive-thyroid/thyroid-medicines.aspx

https://jish-mldtrust.com/love-me-only-at-all-times-the-case-of-a-young-woman-with-hypothyroidism/

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6b4c9dc2-bf57-48a4-9f61-7e4a54f4eadd

Vajikarana: Treatment of Sexual Dysfunctions in Ayurveda

 

Very interesting introductory article

Vajikarana: Treatment of sexual dysfunctions based on Indian concepts

P. K. Dalal, Adarsh Tripathi, and S. K. Gupta 

Indian J Psychiatry. 2013 Jan; 55(Suppl 2): S273–S276.  doi: 10.4103/0019-5545.105550

PMCID: PMC3705695PMID: 23858267

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705695/

https://charaka.org/vajikarana/

Vajikarana Adhyaya

Chikitsa Sthana Chapter 2. Aphrodisiac therapy, virility and treatment of sexual dysfunctions

https://www.carakasamhitaonline.com/index.php/Vajikarana_Adhyaya

Vajikarana : Sexology in Ayurveda

Prof. Dr. Pandurang Kulkarni, Dr. Swapnil Daspute, Prof. Dr. Abhinandan Muke, Prof. Dr. Atul Rakshe, Dr. Ruturaj Kadam Patil

Deerghayu International, 04-Oct-2020 - Social Science - 194 pages

' Sex is one of basic desire in animal kingdom. Every body should take care of own body , mind and soul. Food is very important. Ayurveda has used it as Rasayana/ rejuvenator of body and mind. Food and plants are used as aphrodisiacs meaning Vajikaran. This is very important branch of Ayurveda. Various sexual problems related to Males are described with remedies.

https://books.google.co.in/books/about/Vajikarana_Sexology_in_Ayurveda.html?id=6BQBEAAAQBAJ

Corona Disease 19 - Covid 19 - Treatment - Research Papers and News Summaries

Long Covid

Gastrointestinal sequelae 90 days after discharge for COVID-19

The Lancet, VOLUME 6, ISSUE 5, P344-346, MAY 01, 2021

https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00076-5/fulltext

COVID-19 infection causing residual gastrointestinal 

symptoms – A single UK Centre Case Studies

Clinical Medicine 2022, Vol 22 No 2 March 2022

https://www.rcpjournals.org/content/clinmedicine/early/2022/02/01/clinmed.2021-0522.full-text.pdf

Long-term complications of COVID-19

Amar D. Desai,* Michael Lavelle,* Brian C. Boursiquot and Elaine Y. Wan

21 DEC 2021https://doi.org/10.1152/ajpcell.00375.2021

American Journal of Physiology-Cell PhysiologyVol. 322, No. 1

https://journals.physiology.org/doi/full/10.1152/ajpcell.00375.2021

Google Search Terms:  Research Cure for Covid

Covid Treatment Guidelines
https://covid19treatmentguidelines.nih.gov/introduction/


Covid 19 Therapeutics Tracker
https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-therapeutics-tracker

About Solidarity Clinical Trials - WHO
https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments

Weaning from Mechanical Ventilator

https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/critical-care-medicine/difficulty-weaning-from-mechanical-ventilation-failure-to-wean-respiratory-failure-ventilator-dependence/

14 Dec 2020

E-dimer

https://journals.lww.com/md-journal/Fulltext/2020/07310/D_dimer_surge_and_coagulation_disorders_in.119.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439969/#:~:text=In%20conclusion%20higher%20admission%20D,among%20patients%20with%20COVID%2D19.

https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-020-00466-z

15  May update



May 14, 2020

NIH begins clinical trial of hydroxychloroquine and azithromycin to treat COVID-19
Study enrolling adults with mild to moderate COVID-19 in the United States.
https://www.nih.gov/news-events/news-releases/nih-begins-clinical-trial-hydroxychloroquine-azithromycin-treat-covid-19

14.05.2020
WHO to study Madagascar's drug to treat COVID-19
The World Health Organization (WHO) on Thursday said that it is in touch with Madagascar over its herbal drink Covid Organics (CVO) -- believed to cure coronavirus or COVID-19 patients.
https://www.aa.com.tr/en/africa/who-to-study-madagascars-drug-to-treat-covid-19-/1840971

13 May 2020

By mid-April, the Food and Drug Administration website had listed 72 active Covid drug trials. So far, only one drug, remdesivir, has shown promise in a major, randomized control trial to lessen the recovery time of Covid patients.

On April 17,  co-authors from institutions around the world published a paper detailing test of 12,000 drugs and identified 30 that appear to stop the virus from destroying human cells  on the preprint server bioRxiv.org. (The paper is currently being peer-reviewed for publication in a journal.) Out of the 30,  four have already been clinically tested for other uses. This helps others to plan clinical trials.
https://www.nytimes.com/2020/05/13/magazine/can-team-science-yield-a-covid-19-treatment.html




12 May 2020
COVID-19: 3-drug combo treatment may be successful
A phase II clinical trial has found that a combination of three drugs — interferon beta-1b, lopinavir-ritonavir, and ribavirin — plus standard care is successful in treating mild-to-moderate cases of COVID-19.

The results of a phase II trial suggest that a combination of three drugs may safely treat COVID-19.
This three-drug combination also shortens the duration of viral shedding — that is, the period during which the virus is detectable in a person’s body and transmissible to others. (Published in Lancet May 2020)

https://www.medicalnewstoday.com/articles/covid-19-3-drug-combo-treatment-may-be-successful

12 May
The World Health Organization said  that some treatments appear to be limiting the severity or length of the COVID-19 disease. It is a positive development.
In April,  WHO  said that there were 83 coronavirus vaccines in development globally, with six candidates -- half of them in China -- already in human trials.
https://www.livemint.com/news/world/who-says-some-treatments-appear-to-be-limiting-severity-of-coronavirus-11589282059930.html


9 May 2020

Anti-malaria drug hydroxychloroquine fails another test as a Covid-19 treatment.

Hydroxychloroquine is the only drug approved for treating hospitalised Covid-19 patients in India, where it is given in combination with the antibiotic azithromycin.

An observational study published in the New England Journal of Medicine (NEJM) concluded that the use of hydroxycholoquine neither lessened the need for patients requiring breathing assistance nor the risk of death.  1,376 consecutive patients in the emergency room with Covid-19 symptoms in the New York-Presbyterian Hospital and Columbia University Irving Medical Center in New York City were given the medicine.


Randomised-control trial evidence in larger numbers is needed and there is one , such multi-country solidarity trial being conducted by World Health Organization.  India is also participating in the solidarity trial.

Hydroxychloroquine is the only drug approved for treating hospitalised Covid-19 patients in India, where it is given in combination with the antibiotic azithromycin. It is also being given to health care workers and people at risk of exposure as a prophylaxis for Covid-19,

A small study in Brazil  was suspended after researchers found that high doses are required to fight Covid and the high does led to irregular heartbeats (heart arrhythmia).
https://www.hindustantimes.com/india-news/anti-malaria-drug-fails-another-test-as-a-covid-19-treatment-says-study/story-IadOtW6iRHIf7LMCA6AvSN.html

updated 4.4.2022, 13.12.2020.

Thyroid Problems and Diseases

http://www.drug2day.com/index.php/drug/display/21558


India Medicine Prices


Brand
Company

ELTROXIN
GSK

PROLOID
(PARKE DAVIS) PFIZER




ROXIN
ZYDUS CADILA



THYROCHEK
MANKIND


THYRONORM
KNOLL (ABBOTT)


THYROUP
LUPIN

THYROWIN
PIRAMAL H.C

THYROX
MACLEODS

Adv Ther. 2019; 36(Suppl 2): 30–46.

Published online 2019 Sep 4. doi: 10.1007/s12325-019-01078-2

PMCID: PMC6822824

PMID: 31485977

Levothyroxine Dose Adjustment to Optimise Therapy Throughout a Patient’s Lifetime

Leonidas H. Duntascorresponding author1 and Jacqueline Jonklaas2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822824/

Effects of Altering Levothyroxine Dose on Energy Expenditure and Body Composition in Subjects Treated With LT4 

Mary H Samuels, Irina Kolobova, Meike Niederhausen, Jonathan Q Purnell, Kathryn G Schuff

The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 11, November 2018, Pages 4163–4175, https://doi.org/10.1210/jc.2018-01203

No effect was found in the study.

https://academic.oup.com/jcem/article/103/11/4163/5078436

Does Hypothyroidism Affect Gastrointestinal Motility?

Hindawi

January 2009, Gastroenterology Research and Practice 2009(1687-6121):529802

DOI:10.1155/2009/529802

https://www.researchgate.net/publication/41910901_Does_Hypothyroidism_Affect_Gastrointestinal_Motility

ud. 4.4.2022, 30.3.2022

Pub 24.1.2016

Cancer - Information - Bulletin Board

 

A blog by cancer survivor

https://radioactiveraz.wordpress.com/

MARCH 3, 2022

Scientists discover molecule that kills pancreatic cancer cells

by Roswell Park Comprehensive Cancer Center

https://medicalxpress.com/news/2022-03-scientists-molecule-pancreatic-cancer-cells.html

Glycogen Metabolism

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019055/

Daily Water Loss due to Evaporation and Urination

 Distribution of Body Water

Total body water constitutes about 70 percent of lean body mass and is most simply divided into two major compartments: (a) intracellular water, which represents 50 percent of body weight or 35 liters in a 70-kg man, and (b) extracellular water, which represents 20 percent of body weight or 14 liters. The latter compartment is subdivided into plasma volume (5 percent body weight) and interstitial fluid volume (15 percent body weight). Intracellular water is not readily measured. It is calculated from measurements of total body water and extracellular fluid volume.

Respiratory water loss can range from 200 ml per day when breathing humidified air to 1500 ml per day when exercising at high altitude. 

Water loss from cutaneous evaporation could range from 500 ml per day at rest in a cool environment to 10 liters per day during exercise in the heat. 

Fecal losses could range from 100 ml per day when on a mixed diet to 32 liters per day or more in a patient with diarrhea. 

Obligatory urine volume is limited by the concentrating power of the kidneys, but it can vary from 250 to 1400 ml per day depending on diet. Urine volume is usually 700 ml per day, but a high-protein diet demands more obligatory water to excrete the osmotically active products of protein metabolism.

Nutritional Needs in Hot Environments: Applications for Military Personnel in Field Operations.

https://www.ncbi.nlm.nih.gov/books/NBK236237/

Cancer Medicines - Prices

 

https://dir.indiamart.com/impcat/oncology-drug.html

https://www.frontiersin.org/articles/10.3389/fpubh.2021.628744/full

Weight Loss Advice, Science, Suggestions and Tips - Telugu - బరువు తగ్గడానికి సైన్సు, ఆహారం - సలహాలు

Dr Dhurandhar's Fat-loss Diet
Dr Nikhil Dhurandhar
HarperCollins, 10-Jan-2018 - Health & Fitness
https://books.google.co.in/books?id=EpNGDwAAQBAJ


The Protein Power Diet  - This topic is mentioned in Dhurandhar's book.
Less than 20% of calories from carbs
By Kathleen M. Zelman, MPH, RD, LD
https://www.webmd.com/diet/a-z/protein-power-what-it-is

Weight Management: State of the Science and Opportunities for Military Programs

Institute of Medicine, Food and Nutrition Board, Committee on Military Nutrition Research, Subcommittee on Military Weight Management

National Academies Press, 01-Dec-2003 - Medical - 276 pages

The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance.

The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment.

To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.

https://books.google.co.in/books?id=n_2bAgAAQBAJ

బరువు తగ్గడానికి సైన్సు - జాసన్ ఫంగ్ గారి వ్యాసాల లంకెలు క్రింద ఇవ్వబడ్డాయి. కొన్ని రోజుల తర్వాత వాటి సారాంశం తెలుగులో ఇవ్వబడుతుంది

బరువు తగ్గడం సాధ్యమే - సులువే - పద్ధతి తెలుసు కోండి - ప్రయత్నించండి
https://www.youtube.com/watch?v=DvBKTgONhSo
___________________

___________________


బరువు తగ్గడానికి ఆహారం - సలహాలు
https://www.youtube.com/watch?v=q1Wp7rx4XXA

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రోజుకి కెలోరీలు ఎన్ని కావాలి? బరువు తగ్గాలంటే ఎన్ని కెలోరీలు తీసుకోవాలి?
https://www.youtube.com/watch?v=iG44f48gHR0

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Tips

56 Ways to Lose Weight Accordig to Science

http://www.msn.com/en-in/health/fitness/56-ways-to-lose-weight-forever-according-to-science/ss-BBsEOiV?li=CCqKrn&ocid=SK2MDHP

Weight loss industry is $20 billion


1. Eat a good breakfast - You are likely to eat less in the rest of the day.

2. Eat dessert or sweet at the end of breakfast - You are likely to eat less in the rest of the day as well as during many days.

3. eat more fibre

4. Quit drinking carbonated drinks

5. Buy and store vegetables and eat them.

6. Use more vegetarian protein. Replace meat.

7. Increase dairy items.

8. Have adequate protein intake

9. Coffee drinking may increase your metabolism

10.Be careful with wine intake. One serving may give you 125 calories. 3 servings is almost a meal.



__________

“Protein Power” by Michael Eades, MD
https://vimeo.com/27670888

Weight Reduction  Science

బరువు తగ్గడానికి సైన్సు - జాసన్ ఫంగ్ గారి వ్యాసాలు 

How to Lose Weight I
https://idmprogram.com/lose-weight/

The MultiFactorial Nature of Obesity – How to Lose Weight II
https://idmprogram.com/multifactorial-nature-obesity-lose-weight-ii



Bibliography

THE ROLE OF LEPTIN IN ENERGY HOMEOSTASIS IN HUMANS
Rosenbaum and Leibel, July 2014
Accepted Preprint first posted on 25 July 2014 as Manuscript JOE-14-0358
http://joe.endocrinology-journals.org/content/early/2014/07/25/JOE-14-0358.full.pdf

A missing link in bodyweight homeostasis: The catabolic signal of the overfed state
Yann Ravussin,1,3 Rudolph L. Leibel,2,3 and Anthony W. Ferrante, Jr.1,3
Cell Metab. 2014 Oct 7; 20(4): 565–572.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191848/


2004
Long-term effects of a ketogenic diet in obese patients
No adverse effects
OBJECTIVE:
To determine the effects of a 24-week ketogenic diet (consisting of 30 g carbohydrate, 1 g/kg body weight protein, 20% saturated fat, and 80% polyunsaturated and monounsaturated fat) in obese patients.
Exp Clin Cardiol. 2004 Fall; 9(3): 200–205.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/

2003
Low carb versus Low fat diet

Brehm et al showed that obese women on a low carbohydrate ketogenic diet lost 8.5 kg over six months compared with 4.2 kg lost by those in the low fat diet group (P<0.001). Twenty-two subjects from the low carbohydrate ketogenic diet and 20 subjects from the low fat diet completed the study, with both groups reducing their energy intake by approximately 450 kcal from the baseline level.

In another study performed in 132 severely obese subjects for six months (Samaha et al.), there was greater weight loss in the low carbohydrate ketogenic diet group than in the low fat diet group (5.8 kg versus 1.9 kg, P=0.002). Both of these studies support the findings presented in the present paper.

Brehm BJ, Seeley RI, Daniels SR, D’Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab. 2003;88:1617–23.

Samaha FF, Iqbal N, Seshadri P, et al. A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med. 2003;348:2074–81.


2018
https://books.google.co.in/books?id=qndKDwAAQBAJ

The Complete Guide to Fasting: Heal Your Body Through Intermittent, Alternate-Day, and Extended Fasting
Jimmy Moore, Dr. Jason Fung
Victory Belt Publishing, 18-Oct-2016
https://books.google.co.in/books?id=1U4qDwAAQBAJ


Updated  8 Feb 2022, 7 February 2018,  28 May 2017/

Vegetarian Diet Plan for 60 kg - 70 kg - 80 kg Body Weight Persons

These diet plans are for adequate nutrition and weight maintenance. For weight reduction, lesser amount of calories has to be taken. Exercise has to be increased to increase calorie consumption.

Protein requirement is one gram per kg. of body weight. The intake of grams (pulses and nuts) is varied accordingly. Rice contains 6% protein, wheat 10% and grams between 20% to 25%.

Recommended Diet for 60 kg weight persons

150 gm  grams (pulses)  (600 cal)

150 gm  grains (rice/wheat)  (600 cal)

500 ml  milk (3% fat)  (300 cal)

25 gm (alsi seeds/melon seeds/nuts) 150 cal)

Vegetables

30 gm butter/peanut butter/ghee/oil with vegetables (270 cal)

Fruits (100 cal)

Total 2020 cal,  Appx. 60 gm protein, 45 gm fat

Recommended Diet for 70 kg weight persons

200 gm  grams (pulses)  (800 cal)

150 gm  grains (rice/wheat)  (600 cal)

500 ml  milk (3% fat)  (300 cal)

25 gm (alsi seeds/nuts) 150 cal)

Vegetables

30 gm ghee/oil with vegetables (270 cal)

Fruits (100 cal)

Total 2220 cal,  Appx. 70 gm protein, 45 gm fat

Recommended Diet for 80 kg weight persons

200 gm  grams (pulses)  (800 cal)

175 gm  grains (rice/wheat)  (700 cal)

500 ml  milk (3% fat)  (300 cal)

50 gm (alsi seeds/nuts) (300 cal)

Vegetables

30 gm ghee/oil with vegetables (270 cal)

Fruits (100 cal)

Total 2470 cal,  Appx. 80 gm protein, 45 gm fat

As activity increases more fat intake can be taken. One gram per one kg. of body weight can be taken like one gram per one kg.of protein. After increasing fat, more energy can be obtained from grains.

https://blog.nasm.org/how-many-grams-of-fat-per-day-to-lose-weight

https://my.clevelandclinic.org/health/articles/11208-fat-what-you-need-to-know

Recommended Diet for 50 kg weight persons

100 gm  grams (pulses)  (400 cal)

150 gm  grains (rice/wheat)  (600 cal)

500 ml  milk (3% fat)  (300 cal)

25 gm (alsi seeds/nuts) 150 cal)

Vegetables

30 gm ghee/oil with vegetables (270 cal)

Fruits (100 cal)

Total 1820 cal,  Appx. 50 gm protein, 45 gm fat

Weight Loss Story and Journal - 80 kg to 60 kg

Concor & Inapure Comparison

 

Concor

Bisoprolol Fumarate 5 Mg Tablet Beta-Blockers (Systemic) - Uses, Side Effects, and More

COMMON BRAND(S): ZEBETA

GENERIC NAME(S): BISOPROLOL FUMARATE

Bisoprolol is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This medication belongs to a class of drugs known as beta blockers. It works by blocking the action of certain natural chemicals in your body such as epinephrine on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart.

https://www.webmd.com/drugs/2/drug-14206/bisoprolol-fumarate-oral/details

https://www.axahealth.co.uk/health-information/conditions/heart/how-can-i-quit-taking-concor-5mg/

https://www.practo.com/medicine-info/concor-5-mg-tablet-23310

https://www.1mg.com/drugs/concor-5-tablet-117202

Ivabradine Tablet - Uses, Side Effects, and More

COMMON BRAND(S): CORLANOR

GENERIC NAME(S): IVABRADINE

Uses

This medication is used to treat heart failure. It is used by adults to help prevent the heart failure from getting worse and needing treatment in a hospital. It is also used by children who have heart failure due to an enlarged heart (dilated cardiomyopathy). Heart failure is a condition where your heart does not pump blood as well as it should. Ivabradine works by making your heart beat more slowly.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

https://www.webmd.com/drugs/2/drug-159226/ivabradine-oral/details

https://medlineplus.gov/druginfo/meds/a615027.html

https://www.practo.com/medicine-info/inapure-5-tablet-46591

https://www.1mg.com/drugs/inapure-5-tablet-33300

Coronavirus - Covid19 - 2020 Pandemic - India Events - World Events

https://timesofindia.indiatimes.com/india/coronavirus-live-updates-india-and-world-december-2/liveblog/88039431.cms

https://www.livescience.com/topics/coronavirus

https://www.livescience.com/topics/live/coronavirus-live-updates


https://ncov2019.live/data

12.1.2022

With 27,561 new circumstances, Delhi sees rise in daily Covid-19 tally 

12 Jan 2022

This is the second-highest single-day rise in Covid-19 since the starting of the pandemic. On April 20, 2021, the  town noticed 28,395 infections.

https://newslogic.in/city-news/delhi-news/with-27561-new-circumstances-delhi-sees-rise-in-daily-covid-19-tally-latest-news-delhi/

https://news.alphastarcity.com/india-update/delhi-registers-second-highest-rise-in-covid-cases-since-pandemic-began-deaths-positivity-rate-today/

3rd Jan 2022

One Million Cases per Day in USA

More than a million people in the U.S. were diagnosed with Covid-19 on Monday (3rd Jan 2022).  

Monday’s number is almost double the previous record of about 590,000 set just four days ago in the U.S. 

The highest number outside the U.S. was in India during  delta surge, 414,000  on May 7, 2021.

https://time.com/6132659/us-record-covid-cases/

4 Jan 2021

Omicron pushes New York virus hospitalizations past 2021 peak.

The number of New Yorkers hospitalized with coronavirus infections topped 9,500 on Monday, surpassing the peak reached during last year’s winter wave,

https://www.washingtonpost.com/nation/2022/01/03/covid-omicron-variant-live-updates/

414,000 in India

https://www.indiatoday.in/coronavirus-outbreak/story/covid-cases-deaths-india-may-7-vaccine-lockdown-1799762-2021-05-07

4.1.2021

10,860 cases in Mumbai today.

https://timesofindia.indiatimes.com/city/mumbai/mumbai-news-live-updates-covid-cases-omicron-third-wave-vaccination-bmc-schools-4-january-2022/liveblog/88673180.cms

Highest in 2021 in Mumbai

The second wave of coronavirus was at its peak in Mumbai in April 2021, and 9,000 cases were registered daily for the first three weeks. The highest number of Covid cases were reported on April 4, 2021 with 11,206 cases.

https://news.abplive.com/news/india/112-more-deaths-occurred-in-mumbai-in-april-2021-as-compared-to-2020-reveals-rti-1466794

APRIL 25, 2021

Mumbai on Saturday reported 5,888 cases - a nearly 50 percent drop from its highest single-day spike of 11,163 on April 4 - marking the Maharashtra capital’s lowest tally in three weeks.

https://www.news18.com/news/india/with-a-50-drop-from-its-peak-mumbai-covid-19-cases-at-3-week-low-are-curbs-working-3674219.html

Apr 07, 2021

Mumbai recorded yet another spike of over 10,000 new Covid-19 cases (10,442 to be exact) in the last 24 hours, according to state government's health bulletin on Wednesday.

This is the third time this month that Mumbai has recorded more than 10,000 cases. On Tuesday, the country's financial capital recorded 10,030 new Covid-19 cases, while on Sunday, it reported 11,163 new cases, the highest since the pandemic began.

https://www.hindustantimes.com/india-news/mumbai-again-records-over-10-000-new-covid-19-cases-maha-tally-up-by-nearly-60k-101617808797701.html

https://sacoronavirus.co.za/2021/12/05/update-on-covid-19-sunday-05-december-2021/

https://www.nicd.ac.za/latest-confirmed-cases-of-covid-19-in-south-africa-4-december-2021/

https://www.nicd.ac.za/latest-confirmed-cases-of-covid-19-in-south-africa-2-december-2021/

First Omicron case reported in the US

By Adam Renton, Brad Lendon, Sheena McKenzie, Ed Upright, Meg Wagner, Melissa Macaya and Melissa Mahtani, CNN

Updated 10:38 p.m.  December 1, 2021

https://edition.cnn.com/world/live-news/omicron-covid-19-variant-12-01-21/index.html

How do death rates from COVID-19 differ between people who are vaccinated and those who are not?

by Edouard Mathieu and Max Roser

November 23, 2021

https://ourworldindata.org/covid-deaths-by-vaccination

19 Nov 2021

Austria imposed full lockdown. Germany is also considering

https://www.reuters.com/markets/europe/austria-imposes-full-lockdown-germany-may-follow-covid-grips-europe-2021-11-19/

14 November 2021

30 May 2020 - 8,336 case

18 Sep 2020 - 93,000+

1 Feb 2021 - 8,335

5 May 2021 - 412,000+

14 Nov 2021 -   8,359

October 2021

21.10.2021 News

China is 13th on the list with 74.97 per cent, even though it has fully vaccinated over 100 crore people.

India  administered 100 crore vaccinations  with 20.55 per cent of the population fully vaccinated.

https://indianexpress.com/article/india/india-vs-rest-of-world-what-the-covid-vaccine-numbers-say-7583334/

May 2021

India has seen 1 million Covid deaths so far, The Economist’s model estimates

Estimates suggest there is a 95% probability that the Covid death toll worldwide is between 7.1 mn and 12.1 mn, with a central estimate of 10.2 mn.

20 May, 2021 

https://theprint.in/health/india-has-seen-1-million-covid-deaths-so-far-the-economists-model-estimates/662011/

------------------

https://www.downtoearth.org.in/news/health/covid-19-expect-a-million-deaths-in-india-by-august-1-76700

The Institute for Health Metrics and Evaluation (IHME) is an independent global health research center at the University of Washington.

http://www.healthdata.org/special-analysis/estimation-excess-mortality-due-covid-19-and-scalars-reported-covid-19-deaths

https://covid19.healthdata.org/india?view=mask-use&tab=trend

https://covid19.healthdata.org/global?view=cumulative-deaths&tab=trend

http://www.healthdata.org/

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01052-7/fulltext

--------------------

Maharashtra cases cross 50 lakhs  9 May 2021

https://timesofindia.indiatimes.com/city/mumbai/mumbais-daily-caseload-dips-below-3000-fewer-deaths-too/articleshow/82489041.cms

https://www.ndtv.com/india-news/india-to-get-between-190-250-million-subsidised-covid-vaccines-gavi-2437458

https://www.reuters.com/world/india/covax-says-indias-serum-institute-bound-supply-virus-vaccines-2021-04-09/

https://www.indiatoday.in/coronavirus-outbreak/story/who-says-covax-needs-20-million-vaccine-doses-urgently-1798578-2021-05-04

30 April 2021

135 teachers died due to Corona in poll duty of UP Panchayat elections.

https://theprint.in/india/she-was-8-months-pregnant-was-forced-into-up-poll-duty-that-killed-135-teachers/648092/

19 Dec 2020

Second wave may not come in India.

 If India starts its vaccination programme by the end of this month and vaccinates around 30 crore people, we should be able to control this disease by March 25." Dr K K Agarwal, a cardiologist.

https://www.rediff.com/news/report/there-may-not-be-a-second-covid-peak-in-india-experts/20201219.htm

Surge in California

https://edition.cnn.com/2020/12/18/us/california-covid-surge-alarming-rise/index.html

30 Oct 2020
Vaccine trial analysis
Astrazeneca will do its first  analysis when they are 75 infections in its sample of persons vaccinated. Moderna will do it at 53. Pfizer will do it at 32.

https://www.theguardian.com/world/2020/oct/30/its-possible-the-race-to-approve-a-covid-vaccine-by-christmas

Excess deaths due to covid in USA March 2020 to Oct 2020

https://www.weforum.org/agenda/2020/10/covid19-indirectly-affect-adults-alzheimer-s-dementia-deaths/

14 June 2020
https://www.themoscowtimes.com/2020/06/13/coronavirus-in-russia-the-latest-news-june-13-a69117

Map showing cases in Russia during lockdown period and after lifting.
More than 17% of Moscow residents have coronavirus antibodies.

21 May
21 May
Study proposes lockdown strategy: 50 days on, 30 off
https://www.rediff.com/news/report/coronavirus-study-proposes-lockdown-strategy-50-days-on-30-off/20200521.htm

19 May 2020
1,328 maharashtra police tested positive for Covid
https://news.rediff.com/commentary/2020/may/19/1328-maha-police-test-positive-for-covid19/0613ec97b784147121305a56a08afcd1


May 17, 2020
1 lakh beds soon for COVID-19 treatment in Mumbai: BMC
"The BMC has already increased its bed capacity to 50,000. We will soon achieve the capacity of one lakh beds,"
1500 hundred buildings have one or two cases. There, a floor is being treated a containment area.
690 containment zones are there from where bulk of cases are coming.
https://www.rediff.com/news/report/coronavirus-in-india-1-lakh-beds-soon-for-covid-treatment-in-mumbai-bmc/20200517.htm

15 May


India now has a total of 8,694 facilities comprising 919 dedicated COVID-19 hospitals, 2,036 health centres and 5,739 care centres with a total of 2,77,429 beds for severe and critical cases, 29,701 Intensive Care Unit (ICU) beds and 5,15,250 isolation beds, are available.
https://www.rediff.com/news/report/79-pc-of-indias-covid-19-cases-are-from-30-municipal-areas/20200515.htm

14 May

Pool testing approved for Covid

Samples of 25 persons are pooled and tested. If negative all are treated a negative.
If it is positive, individual samples are tested.
https://www.rediff.com/news/report/coronavirus-in-india-govt-plans-rapid-pool-testing-of-migrants-returnees/20200514.htm

5 May 2020
FELUDA Test Kit for Covid - India Developed

https://www.rediff.com/news/interview/coronavirus-in-india-how-feluda-will-detect-covid-19-in-minutes/20200505.htm


Medical facilities to fight corona

https://economictimes.indiatimes.com/industry/healthcare/biotech/healthcare/covid-19-war-and-indias-readiness/healthcare-facilities/slideshow/75502229.cms

25 April 2020
Ahmedabad - Danger Forecast
"At present, the rate of doubling of cases in Ahmedabad is four days, which means that cases double every four days. If this rate continues, we will have 50,000 cases by May 15 and around 8 lakh by May 31."

"Our target is to bring down this rate to eight days. This will be a very difficult task because very few countries have achieved it,"
https://www.indiatoday.in/india/story/ahmedabad-may-have-8-lakh-covid19-cases-by-may-end-1670700-2020-04-24


6 April
Bhramar Mukherjee
https://ihpi.umich.edu/news/bhramar-mukherjee-coronavirus-modeling-impact-indias-pandemic-response

2 April 2020
Govt identifies 20 existing, 22 potential COVID-19 hotspots in India. Gives guidelines for creating human resource at 1 for 250 persons.
https://www.rediff.com/news/report/govt-identifies-coronavirus-hotspots-in-india/20200402.htm


31 March 2020

https://www.rediff.com/news/report/rediff-labs-mapped-trend-of-covid-19-cases-in-india/20200401.htm

What about the number of ventilators, ICU beds available and manpower being prepared in Maharashtra to treat serious COVID-19 patients?
As of this moment (this interview was conducted at 9.30 pm India time), March 31, we have almost 1,173 ventilators, 2,695 ICUs and about 10,408 plus isolation beds.

What is the ratio out of COVID-19 positive patients to total tests done?

Maharashtra has reported 302 COVID-19 positive patients out of 6,331 tests done till now. That's like less than five in every 100 people tested are reportedly COVID-19 positive.

15 lakh persons who came to India have to be tested as per Central Govt.s order it seems in the country.
https://www.rediff.com/news/interview/we-are-prepared-for-the-worst/20200401.htm


https://ncov2019.live/data

India
Date                 Time       Persons with infection          Deaths
29.3.2020         8.00 am        987                                     24

26 March 2020
India tested 25,254 samples as of 8 p.m. on March 25, of which 581 (2.3%) were positive, according to the latest update from the Indian Council of Medical Research. This proportion is comparable with South Korea's (3%) and higher than Taiwan's (1%).
https://www.indiaspend.com/1-in-50-covid-19-tests-in-india-are-coming-out-positive-compared-with-1-in-4-in-italy-1-in-10-in-the-uk/

ICMR initiates buying of 7 lakhs test kits.
https://www.businesstoday.in/sectors/pharma/india-readies-massive-covid-19-testing-plan/story/399260.html


22 March 2020

Predictions for India

By 15 May Max: 161 for 100,000 giving total of  2.2 million cases
With very strict restrictions on interaction among people the low could be 1 per 100,000 giving  13,800 for the country.
https://medium.com/@covind_19/predictions-and-role-of-interventions-for-covid-19-outbreak-in-india-52903e2544e6




Some Events in January 2020



On Jan. 12, Chinese scientists published the genome of the virus, and the W.H.O. asked a team in Berlin to use that information to develop a diagnostic test. Just four days later, they produced a test and the W.H.O. posted online a blueprint that any laboratory around the world could use to duplicate it.

On Jan. 21, China shared materials for its test with the W.H.O., providing another template for others to use.

C.D.C. of USA, insisted on producing their own tests. But a flaw in the initial C.D.C. test, and the agency’s slowness in approving testing by labs other than its own, contributed to weeks of delay in widespread testing and isolating infected in the United States.

Larry Gostin, director of the W.H.O.’s Center on Global Health Law, said the organization relied too heavily on the initial assertions out of Wuhan that there was little or no human transmission of the virus.

 Dr. Michael Ryan, the W.H.O.’s chief of emergency response, said on Feb. 18.  “Right now, the strategic and tactical approach in China is the correct one,” “You can argue whether these measures are excessive or restrictive on people.”

On Jan. 31 — a day after the W.H.O.’s emergency declaration — President Trump moved to restrict travel from China.

The first known case in the United States was confirmed on Jan. 20, after a man who was infected but not yet sick traveled five days earlier from Wuhan to the Seattle area, where the first serious American outbreak occurred.

The W.H.O. said repeatedly that it did not endorse international travel bans, which it said are ineffectual and can do serious economic harm.

A crucial turning point in the pandemic came on Jan. 20, after China’s central government sent the country’s most famous epidemiologist, Zhong Nanshan, to Wuhan to investigate the new coronavirus.  Dr. Zhong delivered a startling message on national television:  The contagion spread quickly between people, doctors were dying and everyone should avoid the city. Dr. Zhong,  83-year-old,  led the fight against the SARS outbreak of 2002 and 2003. Within three days after Dr. Zhong’s warning, China locked down the city, preventing anyone from entering or leaving and imposing strict rules on movement within it. Despite Dr. Zhong’s warning about human-to-human transmission, Tedros Adhanom Ghebreyesus, the W.H.O.’s director-general, said there was not yet any evidence of sustained transmission outside China.

https://www.nytimes.com/2020/04/16/health/WHO-Trump-coronavirus.html